{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:36:44Z","timestamp":1777930604659,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Vascular hamartomas are non-neoplastic developmental anomalies of vessels. Cases of cerebral vascular hamartomas have been previously reported in dogs and cats. A 4-week-old Freiberger foal had shown persistent problems with breathing and swallowing since birth, and bilateral laryngeal paralysis was diagnosed. The foal subsequently developed left sided facial nerve paralysis and a secondary corneal ulcer in the left eye. Necropsy revealed a pinkish mass in the obex region of the brain. The mass was further investigated by histology and immunohistochemistry. Histologically, the mass consisted of many thin-walled, blood-filled vascular structures of variable diameter involving the white matter of the obex. The lining cells were immunohistochemically positive for factor VIII (von Willebrand factor) interpreted as endothelial cells. The endothelial lining showed also variable immunoreactivity for smooth muscle actin and vimentin. Normal neural parenchyma labeled with antibodies directed against glial fibrillary acidic protein and neuron-specific enolase was present between the vascular proliferations. A diagnosis of focal vascular hamartoma in the obex was made. The development of clinical signs is attributed to the compression of the surrounding neural parenchyma.<\/jats:p>","DOI":"10.1177\/1040638714548681","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T03:20:52Z","timestamp":1411788052000},"page":"805-809","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Vascular hamartoma in the central nervous system of a foal"],"prefix":"10.1177","volume":"26","author":[{"given":"Nicole","family":"Borel","sequence":"first","affiliation":[{"name":"Institute of Veterinary Pathology (Borel, Grest), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"},{"name":"Clinic for Equine Internal Medicine, Equine Department (Junge, Wehrli Eser), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Grest","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology (Borel, Grest), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"},{"name":"Clinic for Equine Internal Medicine, Equine Department (Junge, Wehrli Eser), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Junge","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology (Borel, Grest), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"},{"name":"Clinic for Equine Internal Medicine, Equine Department (Junge, Wehrli Eser), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meret","family":"Wehrli Eser","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology (Borel, Grest), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"},{"name":"Clinic for Equine Internal Medicine, Equine Department (Junge, Wehrli Eser), Vetsuisse Faculty, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"bibr1-1040638714548681","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-5-607"},{"key":"bibr2-1040638714548681","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2460\/javma.1982.181.02.172","volume":"181","author":"Baker JC","year":"1982","journal-title":"J Am Vet Med Assoc"},{"key":"bibr3-1040638714548681","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600516"},{"key":"bibr4-1040638714548681","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1997.tb13821.x"},{"key":"bibr5-1040638714548681","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600301"},{"key":"bibr6-1040638714548681","unstructured":"Gasse H: 2010, Gehirn und Hirnnerven [Brain and cranial nerves].\n                      In\n                      : Praxisorientierte Anatomie und Prop\u00e4deutik des Pferdes, ed. Wissdorf H, Gerhards H, Huskamp B, Deegen E, 3rd ed., pp. 293\u2013313. M. & H. Schaper, Hannover, Germany. In German."},{"key":"bibr7-1040638714548681","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1977.tb03974.x"},{"key":"bibr8-1040638714548681","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2460\/javma.1984.184.09.1121","volume":"184","author":"Hargis AM","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"bibr9-1040638714548681","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.12.006"},{"key":"bibr10-1040638714548681","unstructured":"Maxie MG, Robinson WF: 2007, Cardiovascular system.\n                      In\n                      : Pathology of domestic animals, ed. Maxie MG, 5th ed., vol. 3, pp. 102\u2013103. 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