{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:36:49Z","timestamp":1777930609588,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Chinese Shar-Pei dogs have a high prevalence of hypocobalaminemia and are commonly presented with clinical signs suggestive of severe and long-standing gastrointestinal disease such as diarrhea, vomiting, and\/or weight loss. The aim of the current study was to evaluate serum concentrations of inflammatory markers, markers for intestinal disease, and immunological markers in Shar-Peis with hypocobalaminemia or normocobalaminemia (serum cobalamin concentrations within the reference interval). Serum samples from Shar-Peis were collected from various parts of the United States. Serum concentrations of inflammatory markers (i.e., C-reactive protein [CRP], calprotectin [CP], and S100A12), hyaluronic acid (HA, a marker for cutaneous mucinosis), and analytes commonly altered in chronic intestinal diseases (i.e., albumin, zinc, alpha\n                    <jats:sub>1<\/jats:sub>\n                    -proteinease inhibitor [\u03b1\n                    <jats:sub>1<\/jats:sub>\n                    PI], immunoglobulin [Ig]A, and IgM) were compared between Shar-Peis with hypocobalaminemia and Shar-Peis with normocobalaminemia. Serum concentrations of CRP, CP, S100A12, HA, zinc, and c\u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -PI concentrations did not differ between hypocobalaminemic and normocobalaminemic Shar-Peis ( P &gt; 0.05). Serum concentrations of albumin were significantly lower in hypocobalaminemic Shar-Peis (median: 2.5 g\/dl) than in normocobalaminemic Shar-Peis (median: 2.9 g\/dl; P &lt; 0.0001). Higher serum IgA concentrations and lower serum IgM concentrations were observed in hypocobalaminemic Shar-Peis (median: 1.7 g\/l and 0.8 g\/l, respectively) than in normocobalaminemic Shar-Peis (median: 0.7 g\/l and 1.9 g\/l, respectively; both P &lt; 0.0001). In conclusion, no difference was found in serum concentrations of CRP, CP, S100A12, and HA between hypocobalaminemic and normocobalaminemic Shar-Peis whereas some differences were observed in analytes (e.g., albumin, IgA, and IgM) that may be altered in patients with chronic enteropathies.\n                  <\/jats:p>","DOI":"10.1177\/1040638714560881","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T03:09:33Z","timestamp":1418958573000},"page":"31-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia"],"prefix":"10.1177","volume":"27","author":[{"given":"Niels","family":"Gr\u00fctzner","sequence":"first","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Gr\u00fctzner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TX"},{"name":"Microscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romy M.","family":"Heilmann","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Gr\u00fctzner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TX"},{"name":"Microscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon M.","family":"Cranford","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Gr\u00fctzner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TX"},{"name":"Microscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Holzenburg","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences (Gr\u00fctzner, Heilmann, Cranford, Suchodolski, Steiner), Texas A&M University, College Station, TX"},{"name":"Microscopy and Imaging Center, Department of Biology and Department of Biochemistry and Biophysics (Holzenburg), Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan 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