{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:37:08Z","timestamp":1777930628251,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>The objective of the current study was to determine whether detection of Canine distemper virus (CDV)-specific serum antibodies correlates with resistance to challenge with virulent virus. Virus neutralization (VN) assay results were compared with resistance to viral challenge in 2 unvaccinated Beagle puppies, 9 unvaccinated Beagle dogs (4.4\u20137.2 years of age), and 9 vaccinated Beagle dogs (3.7\u20134.7 years of age). Eight of 9 (89%) unvaccinated adult dogs exhibited clinical signs after virus challenge, and 1 (13%) dog died. As compared to adult dogs, the 2 unvaccinated puppies developed more severe clinical signs and either died or were euthanized after challenge. In contrast, no clinical signs were detected after challenge of the 9 adult vaccinated dogs with post-vaccination intervals of up to 4.4 years. In vaccinated dogs, the positive and negative predictive values of VN assay results for resistance to challenge were 100% and 0%, respectively. Results indicate that dogs vaccinated with modified live CDV can be protected from challenge for \u22644.4 years postvaccination and that detection of virus-specific antibodies is predictive of whether dogs are resistant to challenge with virulent virus. Results also indicate that CDV infection in unvaccinated dogs results in age-dependent morbidity and mortality. Knowledge of age-dependent morbidity and mortality, duration of vaccine-induced immunity, and the positive and negative predictive values of detection of virus-specific serum antibodies are useful in development of rational booster vaccination intervals for the prevention of CDV-mediated disease in adult dogs.<\/jats:p>","DOI":"10.1177\/1040638715602291","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T22:18:52Z","timestamp":1441145932000},"page":"576-580","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of serologic tests to predict resistance to\n                    <i>Canine distemper virus<\/i>\n                    \u2013induced disease in vaccinated dogs"],"prefix":"10.1177","volume":"27","author":[{"given":"Wayne A.","family":"Jensen","sequence":"first","affiliation":[{"name":"Heska Corp., Loveland, CO (Jensen, Totten)"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Lappin)"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI (Schultz)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet S.","family":"Totten","sequence":"additional","affiliation":[{"name":"Heska Corp., Loveland, CO (Jensen, Totten)"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Lappin)"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI (Schultz)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Lappin","sequence":"additional","affiliation":[{"name":"Heska Corp., Loveland, CO (Jensen, Totten)"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Lappin)"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI (Schultz)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald D.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Heska Corp., Loveland, CO (Jensen, Totten)"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Lappin)"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI (Schultz)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"bibr1-1040638715602291","first-page":"173","volume":"5","author":"Abdelmagid OY","year":"2004","journal-title":"Vet 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