{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:37:43Z","timestamp":1777930663090,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Based on microscopic and immunohistochemical characterization, we documented spontaneous proliferative and neoplastic lesions in the thyroid and parathyroid glands of nondomestic felids. Ten animals (4 leopards, 3 tigers, and 3 cougars), all with a previous diagnosis of thyroid neoplasia were identified from the University of Tennessee College of Veterinary Medicine database. The mean age of affected animals was 15.9 y. Twelve neoplasms were identified; 2 animals had 2 concurrent neoplasms. After immunohistochemical characterization using a panel of chromogranin A, thyroglobulin, and calcitonin, 7 of the former thyroid neoplasms were diagnosed as thyroid adenomas, 1 was diagnosed as a thyroid carcinoma, and 4 were diagnosed as parathyroid adenomas. No thyroid medullary neoplasms (C-cell tumors) were diagnosed in the current study. Most of the diagnosed neoplasms were benign (11 of 12), and metastasis was not documented in the single carcinoma. Only 2 animals were suspected to have functional neoplasms (1 thyroid adenoma and 1 parathyroid adenoma), based on associated tissue lesions or serum biochemistry. Other documented lesions in the thyroid and parathyroid glands included thyroid nodular hyperplasia ( n = 7), parathyroid hyperplasia associated with chronic renal disease ( n = 2), a thyroid abscess, and a branchial cyst. Parathyroid adenomas were more commonly diagnosed than expected in comparison with domestic cats. We demonstrated that an immunohistochemistry panel for thyroglobulin, calcitonin, and chromogranin A can be used to differentiate neoplasms of thyroid from parathyroid origin in nondomestic felids.<\/jats:p>","DOI":"10.1177\/1040638716672253","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T20:31:07Z","timestamp":1479328267000},"page":"8-13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Spontaneous proliferative and neoplastic lesions in thyroid and parathyroid glands of nondomestic felids"],"prefix":"10.1177","volume":"29","author":[{"given":"Jenny P.","family":"Pope","sequence":"first","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Small Animal Clinical Sciences (Steeil, Ramsay), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Current addresses: Thompson Bishop Sparks State Diagnostic Laboratory, Auburn, AL (Pope)"},{"name":"KDL VetPath, Knoxville, TN (Reel)"},{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington, DC (Steeil)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Steeil","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Small Animal Clinical Sciences (Steeil, Ramsay), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Current addresses: Thompson Bishop Sparks State Diagnostic Laboratory, Auburn, AL (Pope)"},{"name":"KDL VetPath, Knoxville, TN (Reel)"},{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington, DC (Steeil)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Small Animal Clinical Sciences (Steeil, Ramsay), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Current addresses: Thompson Bishop Sparks State Diagnostic Laboratory, Auburn, AL (Pope)"},{"name":"KDL VetPath, Knoxville, TN (Reel)"},{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington, DC (Steeil)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Reel","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Small Animal Clinical Sciences (Steeil, Ramsay), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Current addresses: Thompson Bishop Sparks State Diagnostic Laboratory, Auburn, AL (Pope)"},{"name":"KDL VetPath, Knoxville, TN (Reel)"},{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington, DC (Steeil)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley J.","family":"Newman","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Small Animal Clinical Sciences (Steeil, Ramsay), College of Veterinary Medicine, University of Tennessee, Knoxville, TN"},{"name":"Current addresses: Thompson Bishop Sparks State Diagnostic Laboratory, Auburn, AL (Pope)"},{"name":"KDL VetPath, Knoxville, TN (Reel)"},{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington, DC (Steeil)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"bibr1-1040638716672253","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.03.008"},{"key":"bibr2-1040638716672253","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch13"},{"key":"bibr3-1040638716672253","unstructured":"Capen CC. 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