{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:36:58Z","timestamp":1793479018423,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Acute leukemia is rare in horses. Herein we describe historical, clinicopathologic, and postmortem findings in 6 horses with acute leukemia. Medical records of horses with &gt;20% bone marrow blasts and cytochemical or immunophenotyping results were reviewed. Affected horses were 2\u20138 y of age and of different breeds and sex. Horses were presented acutely with nonspecific signs (e.g., fever, lethargy). Characteristic hemogram findings were bi- or pancytopenia with low blast numbers. Histologic examination revealed extramedullary infiltrates, especially in lymph nodes, spleen, kidney, liver, and lungs. Leukemias were classified as B-cell ( n = 3) and acute myeloid leukemia (AML) ( n = 3). Tumors in 4 cases expressed multiple lineage markers, which complicated classification. Acute leukemia should be suspected in horses with moderate-to-severe bi- or pancytopenia. Blood smears should be reviewed for neoplastic cells, and bone marrow examination is required for diagnosis. Leukemia classification is best achieved using combined morphologic, cytochemical, and immunophenotyping results.<\/jats:p>","DOI":"10.1177\/1040638717707724","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T09:02:54Z","timestamp":1493802174000},"page":"529-535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute leukemia in six horses (1990\u20132012)"],"prefix":"10.1177","volume":"29","author":[{"given":"Emily A.","family":"Barrell","sequence":"first","affiliation":[{"name":"Departments of Clinical Sciences, Cornell University, Ithaca, NY (Barrell, Felippe, Divers), College of Veterinary Medicine, Cornell University, Ithaca, NY"},{"name":"Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY (Asakawa, Stokol), College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori Goto","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences, Cornell University, Ithaca, NY (Barrell, Felippe, Divers), College of Veterinary Medicine, Cornell University, Ithaca, NY"},{"name":"Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY (Asakawa, Stokol), College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Julia B.","family":"Felippe","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences, Cornell University, Ithaca, NY (Barrell, Felippe, Divers), College of Veterinary Medicine, Cornell University, Ithaca, NY"},{"name":"Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY (Asakawa, Stokol), College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Divers","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences, Cornell University, Ithaca, NY (Barrell, Felippe, Divers), College of Veterinary Medicine, Cornell University, Ithaca, NY"},{"name":"Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY (Asakawa, Stokol), College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Stokol","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences, Cornell University, Ithaca, NY (Barrell, Felippe, Divers), College of Veterinary Medicine, Cornell University, Ithaca, NY"},{"name":"Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY (Asakawa, Stokol), College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"bibr1-1040638717707724","first-page":"548","volume":"82","author":"Blanchard-Channell M","year":"1994","journal-title":"Immunology"},{"key":"bibr2-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03229.x"},{"key":"bibr3-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812451603"},{"key":"bibr4-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01031.x"},{"key":"bibr5-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb01247.x"},{"key":"bibr6-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-6-914"},{"key":"bibr7-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12227"},{"key":"bibr8-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.08.012"},{"key":"bibr9-1040638717707724","volume-title":"WHO Classification of Tumors of Haematopoietic and Lymphoid Tissue","author":"Swerdlow SH","year":"2008","edition":"4"},{"key":"bibr10-1040638717707724","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.15-0627"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638717707724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638717707724","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638717707724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:20:41Z","timestamp":1777681241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638717707724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/1040638717707724"],"URL":"https:\/\/doi.org\/10.1177\/1040638717707724","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}