{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:38:01Z","timestamp":1777930681629,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Systemic necrotizing polyarteritis was diagnosed in three 7\u201311-mo-old lambs from the same flock. Aneurysmal dilation and rupture of the gastroduodenal artery in 1 lamb resulted in fatal hemorrhage. All lambs had severe necrotizing vasculitis involving the small intestine, abomasum, mesentery, kidney, and heart with concurrent lymphocytic enteritis. Immunohistochemistry for T- and B-lymphocytes and macrophages found a T-cell\u2013 and macrophage-dominant transmural vascular infiltrate and T-cell\u2013associated enteritis. PCR analysis for pestivirus failed to identify infection in 1 lamb, and more extensive viral microarray techniques applied to the second and third lamb failed to detect viral nucleic acid. The identification of 3 cases within 1 flock raises the possibility of a common etiology; however, no cause was established. A genetic etiology was not considered likely as not all of the lambs were related. The presence of concurrent T-lymphocyte\u2013associated enteritis raises the possibility of an immune-mediated disease process linking the vasculitis and enteric lesions.<\/jats:p>","DOI":"10.1177\/1040638717709856","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T04:56:47Z","timestamp":1495774607000},"page":"733-737","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Systemic necrotizing polyarteritis in three weaned lambs from one flock"],"prefix":"10.1177","volume":"29","author":[{"given":"Mark","family":"Wessels","sequence":"first","affiliation":[{"name":"Finn Pathologists, Weybread, Diss, Norfolk, UK (Wessels, Woodger)"},{"name":"Farm Post Mortem Ltd, Hamsterley, Bishop Auckland, Co Durham, UK (Strugnell)"},{"name":"Castle Veterinary Surgeons, Barnard Castle, Co Durham, UK (Peat)"},{"name":"Animal and Plant Health Agency\u2013Weybridge, Addlestone, Surrey, UK (La 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