{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:10Z","timestamp":1787019010895,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>A 12-y-old neutered male Portuguese Water dog was presented because of a 1-y history of persistent hyporexia, diarrhea, and recurrent pyelonephritis. Abdominal ultrasound revealed hepatic nodules and diffuse splenomegaly, and radiographs revealed a mediastinal mass. Fine-needle aspirates of the liver, spleen, and mediastinal mass were suspicious for lymphoma. Flow cytometry identified small T cells that co-expressed CD4 and CD8 at all sites, most suspicious for thymoma, but lymphoma could not be ruled out. PCR for antigen receptor rearrangements analysis identified polyclonal amplification of the T-cell receptor genes, more consistent with thymoma than lymphoma. Histopathology of the liver and thymic mass confirmed thymoma with hepatic metastasis.<\/jats:p>","DOI":"10.1177\/1040638718791222","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T09:28:34Z","timestamp":1534498114000},"page":"774-778","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Metastatic thymoma in the liver of a dog"],"prefix":"10.1177","volume":"30","author":[{"given":"Valerie","family":"Wiles","sequence":"first","affiliation":[{"name":"Veterinary Cancer Group, Woodland Hills, CA (Wiles)"},{"name":"IDEXX Laboratories Inc., Westbrook, ME (Haddad)"},{"name":"Department of Oncology, The Animal Medical Center, New York, NY (Leibman)"},{"name":"Clinical Immunology Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Avery, Hughes)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Haddad","sequence":"additional","affiliation":[{"name":"Veterinary Cancer Group, Woodland Hills, CA (Wiles)"},{"name":"IDEXX Laboratories Inc., Westbrook, ME (Haddad)"},{"name":"Department of Oncology, The Animal Medical Center, New York, NY (Leibman)"},{"name":"Clinical Immunology Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Avery, Hughes)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Leibman","sequence":"additional","affiliation":[{"name":"Veterinary Cancer Group, Woodland Hills, CA (Wiles)"},{"name":"IDEXX Laboratories Inc., Westbrook, ME (Haddad)"},{"name":"Department of Oncology, The Animal Medical Center, New York, NY (Leibman)"},{"name":"Clinical Immunology Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Avery, Hughes)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Avery","sequence":"additional","affiliation":[{"name":"Veterinary Cancer Group, Woodland Hills, CA (Wiles)"},{"name":"IDEXX Laboratories Inc., Westbrook, ME (Haddad)"},{"name":"Department of Oncology, The Animal Medical Center, New York, NY (Leibman)"},{"name":"Clinical Immunology Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Avery, Hughes)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Veterinary Cancer Group, Woodland Hills, CA (Wiles)"},{"name":"IDEXX Laboratories Inc., Westbrook, ME (Haddad)"},{"name":"Department of Oncology, The Animal Medical Center, New York, NY (Leibman)"},{"name":"Clinical Immunology Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO (Avery, Hughes)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"bibr1-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1136\/vr.109.22.490"},{"key":"bibr2-1040638718791222","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2460\/javma.1994.205.07.1007","volume":"205","author":"Atwater SW","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"bibr3-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00962.x"},{"key":"bibr4-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.06.014"},{"key":"bibr5-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286161"},{"key":"bibr6-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12196"},{"key":"bibr7-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1038\/nri798"},{"key":"bibr8-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12343"},{"key":"bibr9-1040638718791222","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb00716.x"},{"key":"bibr10-1040638718791222","first-page":"280","volume":"25","author":"Mitcham SA","year":"1984","journal-title":"Can Vet J"},{"key":"bibr11-1040638718791222","first-page":"91","volume":"48","author":"Moffet AC.","year":"2007","journal-title":"Can Vet J"},{"key":"bibr12-1040638718791222","doi-asserted-by":"publisher","DOI":"10.2460\/javma.250.4.387"},{"key":"bibr13-1040638718791222","unstructured":"Parham P. 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