{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:38:53Z","timestamp":1777930733332,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Brucella canis is a cause of canine infertility and abortion. Veterinarians and veterinary laboratorians screen for antibodies to B. canis with serologic tests including a rapid slide agglutination test (RSAT; D-Tec CB, Zoetis, San Diego, CA). False-positive results are possible because of cross-reactivity to antibodies to some gram-negative bacteria. Cross-reactivity has been reported between antibodies of Brucella abortus and Leptospira spp. with serologic tests for bovine brucellosis; however, this has not been documented with serologic tests for canine brucellosis, to the author\u2019s knowledge. The RSAT was evaluated with the sera from dogs experimentally challenged with 1 of 4 serovars of Leptospira spp.: L. kirschneri serovar Grippotyphosa, or L. interrogans serovars Canicola, Icterohaemorrhagiae, or Pomona. Experimental infections were confirmed through results of microscopic agglutination testing and\/or lateral flow immunochromatography testing. The sera of 32 dogs collected at day 0 and days 7, 10, and 14 yielded negative results with the RSAT. Antibodies produced through experimental infections to these 4 serovars of Leptospira spp. did not cross-react with Brucella antigen with the RSAT; therefore, cross-reactivity of anti-leptospiral antibodies may not be of concern for B. canis rapid slide agglutination testing of dogs.<\/jats:p>","DOI":"10.1177\/1040638718820908","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T06:56:46Z","timestamp":1545202606000},"page":"83-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Antibodies produced by dogs successfully challenged with live\n                    <i>Leptospira<\/i>\n                    spp. did not cross-react to\n                    <i>Brucella<\/i>\n                    antigen in a commercial rapid slide agglutination test that detects antibodies to\n                    <i>Brucella canis<\/i>"],"prefix":"10.1177","volume":"31","author":[{"given":"Matthew R.","family":"Krecic","sequence":"first","affiliation":[{"name":"Zoetis Inc., Parsippany, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"bibr1-1040638718820908","first-page":"371","volume":"56","author":"Carmichael LE","year":"1984","journal-title":"Dev Biol Stand"},{"key":"bibr2-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.04.011"},{"key":"bibr3-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2008.05.012"},{"key":"bibr4-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(95)00122-0"},{"key":"bibr5-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14865"},{"key":"bibr6-1040638718820908","first-page":"4627","volume":"5","author":"Moshkelani S","year":"2011","journal-title":"African J Microbiol Res"},{"key":"bibr7-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1177\/1040638711432004"},{"key":"bibr8-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(02)00229-8"},{"key":"bibr9-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2003.12.010"},{"key":"bibr10-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2005.01.015"},{"key":"bibr11-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12328"},{"key":"bibr12-1040638718820908","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.05.005"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638718820908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638718820908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638718820908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:22:10Z","timestamp":1777681330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638718820908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/1040638718820908"],"URL":"https:\/\/doi.org\/10.1177\/1040638718820908","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}