{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:29:23Z","timestamp":1791588563213,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Tools to measure the acute-phase response have been utilized widely in veterinary medicine. Evaluation by plasma protein electrophoresis (PPEP) has become an increasingly common assay in veterinary clinical pathology. Commercial reagents for serum amyloid A (SAA) have been validated for use in a variety of wildlife species. We analyzed samples from 29 healthy fawns and 60 healthy adult farmed white-tailed deer (WTD; Odocoileus virginianus) using an automated assay for SAA and a semi-automated method for PPEP. The robust statistical method for reference interval generation was used. SAA levels in fawns (0.1\u201326\u2009mg\/L) were found to be significantly higher than those in adults (0.1\u20135\u2009mg\/L, p &lt; 0.01). The mean total protein was significantly lower in fawns (48 \u00b1 10\u2009g\/L, p &lt; 0.01) than in adults (73 \u00b15\u2009g\/L). The albumin-to-globulin ratio was also lower in fawns (0.56 \u00b1 0.14) than in adults (1.25 \u00b1 0.19, p &lt; 0.01). Changes in SAA levels were observed in a variety of clinically abnormal animals. The combined use of the automated and semi-automated assays in our study may provide an additional valuable assessment tool in the care of captive WTD populations, for research studies, and for monitoring free-ranging animals.<\/jats:p>","DOI":"10.1177\/1040638719836150","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T03:19:32Z","timestamp":1552274372000},"page":"458-462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum amyloid A and plasma protein electrophoresis fractions in farmed white-tailed deer"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-153X","authenticated-orcid":false,"given":"Carolyn","family":"Cray","sequence":"first","affiliation":[{"name":"Division of Comparative Pathology, Department of Pathology & Laboratory Medicine, University of Miami School of Medicine, Miami, FL (Cray)"},{"name":"Westover Ridge Equine Partners and Knibb Whitetails, Manchester, MO (RI Knibb, JR Knibb)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne I.","family":"Knibb","sequence":"additional","affiliation":[{"name":"Division of Comparative Pathology, Department of Pathology & Laboratory Medicine, University of Miami School of Medicine, Miami, FL (Cray)"},{"name":"Westover Ridge Equine Partners and Knibb Whitetails, Manchester, MO (RI Knibb, JR Knibb)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Knibb","sequence":"additional","affiliation":[{"name":"Division of Comparative Pathology, Department of Pathology & Laboratory Medicine, University of Miami School of Medicine, Miami, FL (Cray)"},{"name":"Westover Ridge Equine Partners and Knibb Whitetails, Manchester, MO (RI Knibb, JR 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