{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:45:08Z","timestamp":1786697108432,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Zinc oxide (ZnO) is commonly fed to pigs at pharmacologic concentrations (2,000\u20133,000 ppm) for the first 3 wk post-weaning to increase growth and reduce enteric bacterial disease. The safety of this high-dose treatment is assumed based upon lower bioavailability of ZnO compared to other common forms of Zn in feed; however, limited data are available regarding the specific serum and tissue concentrations of Zn expected in animals experiencing overload following feeding of excessive ZnO. Fifty-five 3-wk-old pigs were divided into 5 groups receiving various concentrations of ZnO (0\u20136,000 ppm) for 3 wk. Pigs receiving 6,000 ppm ZnO had higher mean pancreatic Zn concentrations ( p &lt; 0.001) compared to other treatments, and higher pancreatic Zn concentrations were associated with pancreatic acinar cell apoptosis ( p &lt; 0.0001). Hepatic Zn concentrations were highest for pigs receiving 6,000 ppm ZnO (mean \u00b1 SEM; 729 \u00b1 264 ppm) and significantly higher than all other groups ( p &lt; 0.0001), with controls having concentrations &lt;60 ppm. Similarly, serum Zn was highest in pigs receiving 6,000 ppm ZnO (4.81 \u00b1 2.31 ppm) and significantly higher than all groups (controls, &lt;1 ppm). Additionally, as pigs became overloaded with Zn, there were significant reductions in serum Cu and both serum and hepatic Se. Hepatic and serum Zn concentrations &gt;500 ppm and &gt;2 ppm, respectively, are indicative of Zn overload, and dietary trace mineral analysis is warranted if expected inclusion rates are \u22643,000 ppm ZnO.<\/jats:p>","DOI":"10.1177\/1040638719852144","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T02:37:56Z","timestamp":1559875076000},"page":"537-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Zinc overload in weaned pigs: tissue accumulation, pathology, and growth impacts"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-9189","authenticated-orcid":false,"given":"Eric R.","family":"Burrough","sequence":"first","affiliation":[{"name":"Departments of Veterinary Diagnostic and Production Animal Medicine (Burrough), Iowa State University, Ames, IA"},{"name":"Animal Science (De Mille, Gabler), Iowa State University, Ames, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"De Mille","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Diagnostic and Production Animal Medicine (Burrough), Iowa State University, Ames, IA"},{"name":"Animal Science (De Mille, Gabler), Iowa State University, Ames, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K.","family":"Gabler","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Diagnostic and Production Animal Medicine (Burrough), Iowa State University, Ames, IA"},{"name":"Animal Science (De Mille, Gabler), Iowa State University, Ames, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"bibr1-1040638719852144","first-page":"34","volume":"32","author":"Abdel-Mageed AB","year":"1990","journal-title":"Vet Hum Toxicol"},{"key":"bibr2-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04063.x"},{"key":"bibr3-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081202"},{"key":"bibr4-1040638719852144","doi-asserted-by":"publisher","DOI":"10.2527\/1999.7751199x"},{"key":"bibr5-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12046"},{"key":"bibr6-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.4.C1103"},{"key":"bibr7-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1515\/pjvs-2016-0113"},{"key":"bibr8-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.647099"},{"key":"bibr9-1040638719852144","doi-asserted-by":"publisher","DOI":"10.2527\/1999.77102730x"},{"key":"bibr10-1040638719852144","doi-asserted-by":"publisher","DOI":"10.2527\/1993.71113020x"},{"key":"bibr11-1040638719852144","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2005-701"},{"key":"bibr12-1040638719852144","doi-asserted-by":"publisher","DOI":"10.2527\/2000.7841010x"},{"key":"bibr13-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.4.867"},{"key":"bibr14-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12307"},{"key":"bibr15-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90130-8"},{"key":"bibr16-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1999.00853.x"},{"key":"bibr17-1040638719852144","first-page":"109","volume":"9","author":"Kim YR","year":"2014","journal-title":"Int J Nanomedicine"},{"key":"bibr18-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:105:1-3:097"},{"key":"bibr19-1040638719852144","doi-asserted-by":"publisher","DOI":"10.2527\/2000.78112896x"},{"key":"bibr20-1040638719852144","first-page":"275","volume":"116","author":"McClain CJ.","year":"1990","journal-title":"J Lab Clin Med"},{"key":"bibr21-1040638719852144","volume-title":"11th revised ed","author":"National Research Council","year":"2012"},{"key":"bibr22-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1080\/09064709509415847"},{"key":"bibr23-1040638719852144","doi-asserted-by":"publisher","DOI":"10.1016\/0301-6226(95)00039-N"},{"key":"bibr24-1040638719852144","unstructured":"Puls R. 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