{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:00:53Z","timestamp":1782788453474,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011141","name":"Agricultural Research Division, Institute of Agriculture and Natural Resources","doi-asserted-by":"publisher","award":["Veterinary Disease Research Program"],"award-info":[{"award-number":["Veterinary Disease Research Program"]}],"id":[{"id":"10.13039\/100011141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations &gt;2,500\u20133,500\u2009m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369\u2009m). Over a 15-mo period (2009\u20132010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8\u20134.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: 2.4 \u00b1 0.8) and 6 had replacement fibrosis of the right ventricle, whereas 14 had interstitial fibrosis (mean score: 1.2 \u00b1 0.2) and 0 had replacement fibrosis of the left ventricle. Lesions of arteriosclerosis were seen in 9 of 16 cases in 51 of 571 (8.9%) right ventricular coronary arteries, and in 10 of 16 cases in 52 of 366 (14.2%) left ventricular coronary arteries. The probability of coronary arteriosclerosis was greater in papillary ventricular muscle (OR = 11.3; p &lt; 0.0001), left ventricle (OR = 4.8; p &lt; 0.0001), and larger arteries (OR = 1.01; p &lt; 0.0001). Pulmonary arteries and arterioles had lesions compatible with hypoxia-induced pulmonary hypertension. We hypothesize that moderate hypobaric conditions significantly contributed to disease in cattle genetically predisposed to hypoxia-induced pulmonary hypertension. Adiposity, coronary arteriosclerosis, and left ventricular fibrosis may have contributed to the condition; however, the cattle died prior to development of advanced obesity.<\/jats:p>","DOI":"10.1177\/1040638719855108","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T02:37:17Z","timestamp":1559875037000},"page":"509-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Investigation of congestive heart failure in beef cattle in a feedyard at a moderate altitude in western Nebraska"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-7716","authenticated-orcid":false,"given":"Rodney A.","family":"Moxley","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Lincoln, NE (Moxley, Steffen)"},{"name":"Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS (Smith)"},{"name":"Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Clay Center, NE (Grotelueschen)"},{"name":"Midwest Feedlot Services, Kearney, NE (Edwards)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Lincoln, NE (Moxley, Steffen)"},{"name":"Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS (Smith)"},{"name":"Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Clay Center, NE (Grotelueschen)"},{"name":"Midwest Feedlot Services, Kearney, NE (Edwards)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale M.","family":"Grotelueschen","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Lincoln, NE (Moxley, Steffen)"},{"name":"Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS (Smith)"},{"name":"Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Clay Center, NE (Grotelueschen)"},{"name":"Midwest Feedlot Services, Kearney, NE (Edwards)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Edwards","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Lincoln, NE (Moxley, Steffen)"},{"name":"Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS (Smith)"},{"name":"Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Clay Center, NE (Grotelueschen)"},{"name":"Midwest Feedlot Services, Kearney, NE (Edwards)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Steffen","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Lincoln, NE (Moxley, Steffen)"},{"name":"Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS (Smith)"},{"name":"Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska\u2013Lincoln, Clay Center, NE (Grotelueschen)"},{"name":"Midwest Feedlot Services, Kearney, NE 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