{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:39:09Z","timestamp":1777930749297,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007652","name":"instituto nacional de investigaci\u00f3n y tecnolog\u00eda agraria y alimentaria","doi-asserted-by":"publisher","award":["PL-015 N-15156"],"award-info":[{"award-number":["PL-015 N-15156"]}],"id":[{"id":"10.13039\/100007652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Sarcocystis spp. are causative agents of bovine eosinophilic myositis and\/or myocarditis, which are chronic subclinical myopathies that are occasionally responsible for condemnation at slaughterhouses. Sarcocystis cruzi is a protozoan parasite of worldwide distribution transmitted by canids, most commonly associated with subclinical infection in cattle. Although S. cruzi infections can rarely lead to fatal systemic disease, fatal cardiac cases with confirmation of the etiologic diagnosis have not been reported, to our knowledge. We describe herein an unusual case of S. cruzi\u2013induced fatal bovine eosinophilic myocarditis. A 22-mo-old, Holstein\u2013Hereford heifer, in a group of 110 cattle on pasture, manifested growth retardation and died in February 2017. Autopsy revealed myriad yellow-green 1\u20133-mm coalescing foci, surrounded by fibrosis, affecting ~75% of the ventricular myocardium. Pulmonary edema, ascites, and hydrothorax were consistent with chronic congestive heart failure. Histology revealed severe eosinophilic, granulomatous, necrotizing myocarditis, with multinucleate giant cells, fibrosis, and mineralization. Numerous thin-walled protozoan cysts resembling Sarcocystis spp. were present in the necrotic foci and within the sarcoplasm of adjacent cardiomyocytes. PCR and sequencing of the 18S rRNA gene revealed 99.9\u2013100% homology with S. cruzi. Sarcocystosis can be a rare cause of fatal myocarditis in cattle.<\/jats:p>","DOI":"10.1177\/1040638719856651","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T06:29:33Z","timestamp":1560148173000},"page":"656-660","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Fatal\n                    <i>Sarcocystis cruzi<\/i>\n                    \u2013induced eosinophilic myocarditis in a heifer in Uruguay"],"prefix":"10.1177","volume":"31","author":[{"given":"Virginia","family":"Ar\u00e1oz","sequence":"first","affiliation":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Ar\u00e1oz, Silveira, Banchero, Riet-Correa, Giannitti)"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina (Mor\u00e9)"},{"name":"Laboratorio de Inmunoparasitolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina (Mor\u00e9)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"da Silva Silveira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Ar\u00e1oz, Silveira, Banchero, Riet-Correa, Giannitti)"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina (Mor\u00e9)"},{"name":"Laboratorio de Inmunoparasitolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina (Mor\u00e9)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-717X","authenticated-orcid":false,"given":"Gast\u00f3n","family":"Mor\u00e9","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Ar\u00e1oz, Silveira, Banchero, Riet-Correa, Giannitti)"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina (Mor\u00e9)"},{"name":"Laboratorio de Inmunoparasitolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina (Mor\u00e9)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgget","family":"Banchero","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Ar\u00e1oz, Silveira, Banchero, Riet-Correa, Giannitti)"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina (Mor\u00e9)"},{"name":"Laboratorio de Inmunoparasitolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina (Mor\u00e9)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin","family":"Riet-Correa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Ar\u00e1oz, Silveira, Banchero, Riet-Correa, Giannitti)"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina (Mor\u00e9)"},{"name":"Laboratorio de Inmunoparasitolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina (Mor\u00e9)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-6848","authenticated-orcid":false,"given":"Federico","family":"Giannitti","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Ar\u00e1oz, Silveira, Banchero, Riet-Correa, Giannitti)"},{"name":"Consejo 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