{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:39:10Z","timestamp":1777930750219,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>A 5-mo-old Bassett Hound\u2013Labrador Retriever cross was autopsied following a bout of lethargy, inappetence, and bleeding gums. Mucous membranes were white, and the small intestine was blue-black; the colon contained black feces. The spleen was swollen, and multiple lymph nodes were enlarged and hemorrhagic. Microscopically, the small intestine had focal crypt cell necrosis and circumferential transmural vasculitis, the latter the cause of infarction and the blue-black coloration. Lymphocytes were necrotic in spleen and lymph nodes, and erythrophagocytosis was present in some nodes. Vasculitis was present in brain, meninges, lung, liver, and kidneys. Electron microscopy revealed aggregates of 15\u201318 nm round viral particles in damaged crypt cells and in the endothelium of small blood vessels. Electron-dense intracytoplasmic inclusions consisting of paracrystalline-arrayed virus were demonstrated in macrophages in medullary lymph node sinuses. These virions were identified as circovirus, which was confirmed by real-time PCR and sequencing.<\/jats:p>","DOI":"10.1177\/1040638719863102","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T02:35:21Z","timestamp":1562812521000},"page":"732-736","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Canine circoviral hemorrhagic enteritis in a dog in Connecticut"],"prefix":"10.1177","volume":"31","author":[{"given":"Herbert J.","family":"Van Kruiningen","sequence":"first","affiliation":[{"name":"Connecticut Veterinary Medical Diagnostic Laboratory, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Heishima","sequence":"additional","affiliation":[{"name":"Connecticut Veterinary Medical Diagnostic Laboratory, Department of Pathobiology and Veterinary 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