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Inflammatory and degenerative changes were more prominent in the brainstem and consisted of lymphoplasmacytic meningoencephalitis with glial nodules, neuronal necrosis, and neuronophagia. No viral inclusions (Negri bodies) were observed in multiple sections of brain. A fluorescent antibody test on fresh samples of brainstem and cerebellum was confirmatory for the eastern United States raccoon rabies virus variant. Immunoreactivity for rabies virus was detected across all brain sections in both cases but was more prominent in the thalamic and brainstem nuclei, as well as in the medial lemniscus. Rabies is an important differential diagnosis in pigs with neurologic disease.<\/jats:p>","DOI":"10.1177\/1040638719898687","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T05:22:35Z","timestamp":1578547355000},"page":"166-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuropathology and diagnostic features of rabies in a litter of piglets, with a brief review of the literature"],"prefix":"10.1177","volume":"32","author":[{"given":"Christopher L.","family":"Siepker","sequence":"first","affiliation":[{"name":"Iowa State University Veterinary Diagnostic Laboratory, Ames, IA (Siepker)"},{"name":"Department of Pathology (Dalton, Sakamoto, Rissi) and Athens Veterinary Diagnostic Laboratory (Rissi), and Infectious Disease Laboratory, Department of Small Animal Medicine and Surgery (McHale), College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha F.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Iowa State University Veterinary Diagnostic Laboratory, Ames, IA (Siepker)"},{"name":"Department of Pathology (Dalton, Sakamoto, Rissi) and Athens Veterinary Diagnostic Laboratory (Rissi), and Infectious Disease Laboratory, Department of Small Animal Medicine and Surgery (McHale), College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany J.","family":"McHale","sequence":"additional","affiliation":[{"name":"Iowa State University Veterinary Diagnostic Laboratory, Ames, IA (Siepker)"},{"name":"Department of Pathology (Dalton, Sakamoto, Rissi) and Athens Veterinary Diagnostic Laboratory (Rissi), and Infectious Disease Laboratory, Department of Small Animal Medicine and Surgery (McHale), College of Veterinary Medicine, University of Georgia, Athens, 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