{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:39:41Z","timestamp":1777930781352,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Most of the pigs on a farm in Aichi Prefecture, Japan had chronic diarrhea and severe wasting. The pigs had consumed 8,000\u2009ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct\u2013like cells were increased and tested positive for cytokeratin AE1\/AE3, Ki67, PGP9.5, and Sox9. Pancreatic islet cells were decreased and shrunken. The \u03b1 and \u03b4 cells were relatively decreased, and their distribution was abnormal. Islet cells were positive for PGP9.5. The livers and kidneys had high accumulations of zinc (Zn; 788\u2009\u00b5g\/g and 613\u2009\u00b5g\/g, respectively). Copper was deficient in the liver, likely as a result of Zn poisoning. Our immunohistologic examination suggested that the high dose of ZnO could influence the function of islet cells in addition to that of acinar cells. Given that colistin sulfate has been banned as a feed additive in order to reduce antimicrobial use in Japan, the use of ZnO in the livestock industry is expected to increase. Zn supplementation of pig feed must be monitored to prevent Zn poisoning and contamination of soil and water.<\/jats:p>","DOI":"10.1177\/1040638720944368","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T05:50:52Z","timestamp":1595656252000},"page":"689-694","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic pancreatitis in farmed pigs fed excessive zinc oxide"],"prefix":"10.1177","volume":"32","author":[{"given":"Tetsuya","family":"Komatsu","sequence":"first","affiliation":[{"name":"Aichi Prefectural Chuo Livestock Hygiene Service Center, Okazaki, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennosuke","family":"Sugie","sequence":"additional","affiliation":[{"name":"Aichi Prefectural Chuo Livestock Hygiene Service Center, Okazaki, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Inukai","sequence":"additional","affiliation":[{"name":"Aichi Prefectural Chuo Livestock Hygiene Service Center, Okazaki, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Eguchi Swine Clinic, Fuso, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Oyamada","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sawada","sequence":"additional","affiliation":[{"name":"National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-5596","authenticated-orcid":false,"given":"Tomoyuki","family":"Shibahara","sequence":"additional","affiliation":[{"name":"National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"key":"bibr1-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1177\/1040638719852144"},{"key":"bibr2-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.4.C1103"},{"key":"bibr3-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(98)80037-7"},{"key":"bibr4-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1177\/030098589603300608"},{"key":"bibr5-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-017-9737-7"},{"key":"bibr6-1040638720944368","doi-asserted-by":"publisher","DOI":"10.2527\/1993.71113020x"},{"key":"bibr7-1040638720944368","doi-asserted-by":"publisher","DOI":"10.2527\/2001.794934x"},{"key":"bibr8-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90130-8"},{"key":"bibr9-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199703000-00008"},{"key":"bibr10-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.58.109"},{"key":"bibr11-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107641"},{"key":"bibr12-1040638720944368","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2017.22.1.1"},{"key":"bibr13-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.538"},{"key":"bibr14-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.4.893-897.1995"},{"key":"bibr15-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1437S"},{"key":"bibr16-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/111.11.1969"},{"key":"bibr17-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2015.01.008"},{"key":"bibr18-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.8.1434"},{"key":"bibr19-1040638720944368","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.01.006"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638720944368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638720944368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638720944368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:23:43Z","timestamp":1777681423000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638720944368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,25]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1177\/1040638720944368"],"URL":"https:\/\/doi.org\/10.1177\/1040638720944368","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,25]]}}}