{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:39:42Z","timestamp":1777930782075,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Male-to-female sex reversal in horses is a developmental disorder in which phenotypic females have a male genetic constitution. Male-to-female sex reversal is the second most common genetic sex abnormality, after X chromosome monosomy. All male-to-female sex reversal cases studied to date have been found to be infertile. Therefore, a screening test is particularly useful in laboratories doing DNA genotyping in horses. Our laboratory has tested &gt;\u2009209,000 horses for parentage using a panel of microsatellite markers and the sex marker gene amelogenin ( AMEL). Suspect XY sex reversal cases are reported females with a male profile by AMEL testing. After routine genotyping, 49 cases were detected and further tested using the sex-determining region Y ( SRY) gene, confirming the XY SRY-negative genotype of suspect sex reversal cases. When some inconsistencies arose in the initial result, a molecular panel of X- and Y-linked markers was analyzed for these samples. Of the 49 cases, 33 were confirmed as XY SRY-negative. The remaining 16 cases were identified as false-positives as a result of anomalies of AMEL testing in horses.<\/jats:p>","DOI":"10.1177\/1040638720952380","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T07:17:50Z","timestamp":1598858270000},"page":"938-941","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular screening of XY\n                    <i>SRY<\/i>\n                    -negative sex reversal cases in horses revealed anomalies in amelogenin testing"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-2910","authenticated-orcid":false,"given":"Maria M.","family":"Martinez","sequence":"first","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Aplicada, Sociedad Rural Argentina, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Aplicada, Sociedad Rural Argentina, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Ratti","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Aplicada, Sociedad Rural Argentina, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"bibr1-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1111\/age.12543"},{"key":"bibr2-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(05)80057-0"},{"key":"bibr3-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsigen.2014.10.014"},{"key":"bibr4-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1520\/JFS2003018"},{"key":"bibr5-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20903"},{"key":"bibr6-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.62.1109"},{"key":"bibr7-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2013.12.013"},{"key":"bibr8-1040638720952380","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054223787"},{"key":"bibr9-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403011101"},{"key":"bibr10-1040638720952380","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2010.02101.x"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638720952380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638720952380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638720952380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:23:48Z","timestamp":1777681428000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638720952380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/1040638720952380"],"URL":"https:\/\/doi.org\/10.1177\/1040638720952380","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]}}}