{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:16:00Z","timestamp":1792523760103,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002365","name":"China Agricultural University","doi-asserted-by":"publisher","award":["2016YFD0501010"],"award-info":[{"award-number":["2016YFD0501010"]}],"id":[{"id":"10.13039\/501100002365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Fibroblast growth factor 23 (FGF-23) is an independent monitor of the progression of chronic kidney disease (CKD) in human medicine, and FGF-23 may have value as a biomarker in feline CKD. We evaluated the relationship between serum FGF-23 and CKD stages, and the effect of age on FGF-23 in normal cats. We measured FGF-23 and intact parathyroid hormone (iPTH) concentrations by ELISA, with intra- and inter-assay CVs \u2264 15%. The percentage recovery of FGF-23 and iPTH remained stable for up to 7 d in samples stored at \u221220\u00b0C and \u221280\u00b0C. We measured FGF-23 in 304 cats, among which 196 were diagnosed with CKD. The 108 clinically healthy cats were divided into 5 subgroups based on growth stage (0\u20132\u2009y, 3\u20136\u2009y, 7\u201310\u2009y, 11\u201314\u2009y, \u2265 15\u2009y). No statistical difference was found in FGF-23 among age groups ( p = 0.15) or by sex in healthy subjects. Using the International Renal Interest Society guideline, 34 cats were defined as CKD stage 1, 74 stage 2, 51 stage 3, and 37 stage 4. FGF-23 was higher in cats in all CKD stages than in controls. Higher serum phosphorus was observed in stage 3 ( p = 0.04) and 4 ( p &lt; 0.01) compared to controls. iPTH increased as CKD progressed. Pearson analysis indicated a positive linear relationship between FGF-23 and iPTH (control: r = 0.70, p &lt; 0.01; CKD: r = 0.46, p = 0.02). FGF-23 may be a useful biomarker of feline CKD and may precede hyperphosphatemia in advanced feline CKD.<\/jats:p>","DOI":"10.1177\/1040638720985563","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T04:48:14Z","timestamp":1612846094000},"page":"288-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Serum fibroblast growth factor 23 (FGF-23): associations with hyperphosphatemia and clinical staging of feline chronic kidney disease"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-0987","authenticated-orcid":false,"given":"Jiabao","family":"Lin","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqi","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Yu","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, China Agricultural University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, China Agricultural University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofei","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, China Agricultural University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"bibr1-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0233"},{"key":"bibr2-1040638720985563","first-page":"4003","volume":"117","author":"Ben-Dov IZ","year":"2007","journal-title":"J Clin Invest"},{"key":"bibr3-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01659.x"},{"key":"bibr4-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031260"},{"key":"bibr5-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01443.x"},{"key":"bibr6-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2017.06.013"},{"key":"bibr7-1040638720985563","first-page":"815","volume":"19","author":"Endo I.","year":"2009","journal-title":"Clin Calcium"},{"key":"bibr8-1040638720985563","first-page":"223","volume":"26","author":"Endo I.","year":"2016","journal-title":"Clin Calcium"},{"key":"bibr9-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12036"},{"key":"bibr10-1040638720985563","doi-asserted-by":"publisher","DOI":"10.2460\/javma.241.10.1326"},{"key":"bibr11-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080936"},{"key":"bibr12-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12044"},{"key":"bibr13-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706130"},{"key":"bibr14-1040638720985563","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14707"},{"key":"bibr15-1040638720985563","unstructured":"International Renal Interest Society. 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