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The clinical signs progressed over 40\u2009d, and the rhinoceros died. Autopsy revealed significant ascites; a unilateral, 12.5-cm diameter, polypoid mass in the left ovary; a white, firm transmural mass in the right uterine horn; a white, friable mass in the lung; and white-to-tan, friable small nodules in the diaphragm. Histologic examination revealed similar neoplastic cells in the masses in all 4 locations, composed predominantly of epithelial cells proliferating in a tubulopapillary pattern with significant nuclear atypia and numerous atypical mitotic figures (18\u201342\u2009per 2.37\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ). Immunohistochemistry for CK7 (cytokeratin 7) and CK20 (cytokeratin 20) suggest that the ovarian, pulmonary, and diaphragmatic lesions were of ovarian origin and that the ovary was the primary tumor site.\n                  <\/jats:p>","DOI":"10.1177\/1040638720986789","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:38:13Z","timestamp":1610653093000},"page":"366-369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ovarian adenocarcinoma with metastases in a white rhinoceros"],"prefix":"10.1177","volume":"33","author":[{"given":"Soo-Hyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Joon","family":"Seung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha-Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Kyung","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Yeon","family":"Eo","sequence":"additional","affiliation":[{"name":"Conservation and Health Center, Seoul Zoo, Gwacheon-si, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Gu","family":"Yeo","sequence":"additional","affiliation":[{"name":"Conservation and Health Center, Seoul Zoo, Gwacheon-si, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang-Won","family":"Son","sequence":"additional","affiliation":[{"name":"Conservation and Health Center, Seoul Zoo, Gwacheon-si, Gyeonggi-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-7582","authenticated-orcid":false,"given":"Jung-Hyang","family":"Sur","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,10]]},"reference":[{"key":"bibr1-1040638720986789","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10010052"},{"key":"bibr2-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1126-0"},{"key":"bibr3-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1054\/cdip.2001.0063"},{"key":"bibr4-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1309\/2T1Y-7BB7-DAPE-PQ6L"},{"key":"bibr5-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2019.06.028"},{"key":"bibr6-1040638720986789","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2019.778-782"},{"key":"bibr7-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092595"},{"key":"bibr8-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.09.002"},{"key":"bibr9-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2009.08.007"},{"key":"bibr10-1040638720986789","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330x.119888"},{"key":"bibr11-1040638720986789","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0061-RA"},{"key":"bibr12-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30183-9"},{"key":"bibr13-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800312"},{"key":"bibr14-1040638720986789","first-page":"97","volume":"10","author":"Sapierzy\u0144ski R","year":"2007","journal-title":"Pol J Vet Sci"},{"key":"bibr15-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012504904713"},{"key":"bibr16-1040638720986789","doi-asserted-by":"publisher","DOI":"10.1638\/2009-0128.1"},{"key":"bibr17-1040638720986789","unstructured":"Wyss F, et al. Why do greater one-horned rhinoceroses (\n                      Rhinoceros unicornis\n                      ) die?\u2014an evaluation of necropsy reports. In: Szentiks CA, Schumann A, eds. Proceedings of the International Conference on Diseases of Zoo and Wild Animals. Bussulengo\/Verona, Italy: Leibnitz Institute for Zoo and Wildlife Research, 2012:54\u201361. 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