{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:25:41Z","timestamp":1791440741826,"version":"4.3.3"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>The clinical presentations of both liver disease and pancreatitis are nonspecific and overlapping, which may cause difficulty in diagnosis. In our retrospective pilot study, we assessed whether dogs with evidence of portal hypertension and absence of pancreatitis on pancreatic histology have increases in canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6\u2032-methylresorufin) ester (DGGR) lipase. We included dogs that had been presented between 2008 and 2019 if they had normal pancreatic histology, histologically confirmed hepatopathy, and if canine pancreas-specific lipase (Spec cPL; Idexx) or DGGR lipase had been measured. Only dogs with portal hypertension were included. Six dogs fulfilled the inclusion criteria. Four of 6 and 2 of 6 dogs had Spec cPL and DGGR lipase exceeding the upper reference limit, respectively. From the 4 dogs with increased Spec cPL, 2 had concentrations of 200\u2013400\u2009\u00b5g\/L and 2 had concentrations \u2265 400\u2009\u00b5g\/L. Our results suggest that canine portal hypertension might lead to increased Spec cPL and DGGR lipase values in the absence of pancreatitis on histology. Until more evidence in a larger number of dogs with portal hypertension is available, both tests should be interpreted cautiously in the presence of portal hypertension.<\/jats:p>","DOI":"10.1177\/10406387211003987","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T05:05:45Z","timestamp":1617339945000},"page":"548-553","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6\u2032-methylresorufin) ester (DGGR) lipase in dogs with evidence of portal hypertension and normal pancreatic histology: a pilot study"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-4064","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Serrano","sequence":"first","affiliation":[{"name":"Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Paepe","sequence":"additional","affiliation":[{"name":"Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"bibr1-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030618"},{"key":"bibr2-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00691.x"},{"key":"bibr3-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15364"},{"key":"bibr4-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1136\/vetreco-2017-000270"},{"key":"bibr5-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2010.00524.x"},{"key":"bibr6-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00007.x"},{"key":"bibr7-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12521"},{"key":"bibr8-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12158"},{"key":"bibr9-10406387211003987","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1998.213.05.665"},{"key":"bibr10-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1080\/089419300272258"},{"key":"bibr11-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00245.x"},{"key":"bibr12-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12334"},{"key":"bibr13-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb01469.x"},{"key":"bibr14-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1177\/1040638711433598"},{"key":"bibr15-10406387211003987","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16078"},{"key":"bibr16-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12376"},{"key":"bibr17-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02572.x"},{"key":"bibr18-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1177\/104063870601800119"},{"key":"bibr19-10406387211003987","first-page":"278","volume":"82","author":"Ohta H","year":"2018","journal-title":"Can J Vet Res"},{"key":"bibr20-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12652"},{"key":"bibr21-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12262"},{"key":"bibr22-10406387211003987","unstructured":"Rothuizen J, et al. WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases. Saunders Elsevier, 2006:103\u2013116."},{"key":"bibr23-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12818"},{"key":"bibr24-10406387211003987","first-page":"58","volume":"3","author":"Steiner JM","year":"2010","journal-title":"Vet Res"},{"key":"bibr25-10406387211003987","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.722"},{"key":"bibr26-10406387211003987","unstructured":"Steiner JM, et al. DGGR lipase is not a specific substrate for pancreatic lipase. Proc WSAVA World Congress; Bangkok, Thailand; 15\u201318 May 2015. Accessed March 15, 2021. https:\/\/www.vin.com\/doc\/?id=7259064"},{"key":"bibr27-10406387211003987","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.8.1001"},{"key":"bibr28-10406387211003987","first-page":"131","volume":"45","author":"Strombeck DR","year":"1984","journal-title":"Am J Vet Res"},{"key":"bibr29-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00793.x"},{"key":"bibr30-10406387211003987","first-page":"99","volume":"79","author":"Van den Bossche I","year":"2010","journal-title":"Vlaams Diergeneeskundig Tijdschrift"},{"key":"bibr31-10406387211003987","first-page":"697","volume":"43","author":"Wagner AE","year":"1982","journal-title":"Am J Vet Res"},{"key":"bibr32-10406387211003987","unstructured":"Warman S, et al. Canine pancreatic lipase immunoreactivity concentrations in dogs with IMHA. Proc British Small Animal Veterinary Congress; Birmingham, UK; 2008. https:\/\/www.vin.com\/apputil\/content\/defaultadv1.aspx?pId=11254&catId=32164&id=3863096"},{"key":"bibr33-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12293"},{"key":"bibr34-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15467"},{"key":"bibr35-10406387211003987","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12274"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387211003987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387211003987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387211003987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:24:17Z","timestamp":1777681457000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387211003987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/10406387211003987"],"URL":"https:\/\/doi.org\/10.1177\/10406387211003987","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,2]]}}}