{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:39:59Z","timestamp":1777930799659,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>An 8-y-old spayed female Beagle dog was presented with peripheral lymphadenomegaly. Lymph node cytology and flow cytometry led to the diagnosis of large B-cell lymphoma (LBCL). We detected minimal percentages of LBCL cells in peripheral blood and bone marrow samples. However, a monomorphic population of neoplastic cells different from those found in the lymph node was found in the bone marrow. T-cell acute lymphoblastic leukemia was suspected based on flow cytometric immunophenotyping. PCR for antigen receptor rearrangement (PARR) revealed clonal rearrangement of both B-cell and T-cell receptors, and the presence of both neoplastic clones in the lymph node, peripheral blood, and bone marrow. The dog was treated with multi-agent chemotherapy but died 46\u2009d following diagnosis. Tumor staging and patient classification are needed to accurately establish a prognosis and select the most appropriate therapeutic protocol.<\/jats:p>","DOI":"10.1177\/10406387211011024","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T07:47:18Z","timestamp":1619077638000},"page":"792-796","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell acute lymphoblastic leukemia"],"prefix":"10.1177","volume":"33","author":[{"given":"Alessandro","family":"Ferrari","sequence":"first","affiliation":[{"name":"Clinica Veterinaria San Lorenzo, Suisio, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Aresu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Turin, Grugliasco, TO, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-2867","authenticated-orcid":false,"given":"Valeria","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milan, Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"bibr1-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.03.006"},{"key":"bibr2-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-1-32"},{"key":"bibr3-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.9.002214"},{"key":"bibr4-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12378"},{"key":"bibr5-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03062.x"},{"key":"bibr6-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80065-5"},{"key":"bibr7-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-92"},{"key":"bibr8-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12855"},{"key":"bibr9-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.05.003"},{"key":"bibr10-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12593"},{"key":"bibr11-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12155"},{"key":"bibr12-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720963132"},{"key":"bibr13-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12136"},{"key":"bibr14-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00318.x"},{"key":"bibr15-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21353"},{"key":"bibr16-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.07.004"},{"key":"bibr17-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12343"},{"key":"bibr18-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700404"},{"key":"bibr19-10406387211011024","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2017.00076"},{"key":"bibr20-10406387211011024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00200.x"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387211011024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387211011024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387211011024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:24:21Z","timestamp":1777681461000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387211011024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/10406387211011024"],"URL":"https:\/\/doi.org\/10.1177\/10406387211011024","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]}}}