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Therefore, we characterized the pathology of cryptosporidiosis in 2 juvenile raccoons. In addition, we conducted a retrospective search of the database of the California Animal Health and Food Safety laboratory for 1990\u20132019 and found 6 additional cases of cryptosporidiosis in raccoons. Sequencing of cryptosporidia was performed in one autopsied raccoon, and PCR on formalin-fixed, paraffin-embedded tissues in archived cases. The Cryptosporidium skunk genotype (CSkG), a strain of zoonotic relevance, was detected in 6 of 8 cases (75%). Frequently, cryptosporidiosis was associated with enteritis, eosinophilic infiltrates, villus atrophy or blunting and\/or fusion, and crypt abscesses or necrosis. In 7 of the 8 cases, there was confirmed concurrent coinfection with canine distemper virus; 1 case was coinfected with canine parvovirus. Although crypt necrosis is considered a classic lesion of canine parvoviral infection in mesocarnivores and not a hallmark of cryptosporidiosis, results suggest that canine distemper virus is capable of mimicking such lesions in combination with cryptosporidia and immunosuppression.<\/jats:p>","DOI":"10.1177\/10406387211011949","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T03:18:13Z","timestamp":1620530293000},"page":"721-727","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathology of cryptosporidiosis in raccoons: case series and retrospective analysis, 1990\u20132019"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-361X","authenticated-orcid":false,"given":"Viviana","family":"Gonzalez-Astudillo","sequence":"first","affiliation":[{"name":"California Animal Health and Food Safety Laboratory (CAHFS), University of California\u2013Davis, San Bernardino, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew F.","family":"Sheley","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory (CAHFS), University of California\u2013Davis, San Bernardino, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco A.","family":"Uzal","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory (CAHFS), University of California\u2013Davis, San Bernardino, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-8052","authenticated-orcid":false,"given":"Mauricio A.","family":"Navarro","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory (CAHFS), University of California\u2013Davis, San Bernardino, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"bibr1-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007042"},{"key":"bibr2-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1177\/104063879400600301"},{"key":"bibr3-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2015.09.002"},{"key":"bibr4-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.06.013"},{"key":"bibr5-10406387211011949","first-page":"63","volume":"25","author":"Cranfield MR","year":"1984","journal-title":"Can Vet J"},{"key":"bibr6-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819d646d"},{"key":"bibr7-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2001.tb10708.x"},{"key":"bibr8-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268811000860"},{"key":"bibr9-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00135-1"},{"key":"bibr10-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01067-06"},{"key":"bibr11-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1016\/j.parepi.2016.03.008"},{"key":"bibr12-10406387211011949","first-page":"611","volume-title":"Wild Mammals of North America","author":"Gehrt S","year":"2003","edition":"2"},{"key":"bibr13-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35775-3.00007-2"},{"key":"bibr14-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1177\/104063879801000218"},{"key":"bibr15-10406387211011949","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-6089-y"},{"key":"bibr16-10406387211011949","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-10.4.423"},{"key":"bibr17-10406387211011949","unstructured":"International Union for Conservation of Nature (IUCN). 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