{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:11Z","timestamp":1787019011326,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>We characterized the immunohistochemical expression profiles of dysgerminomas from a 16-y-old maned wolf and 13 domestic dogs using the following biomarkers: Sal-like protein 4 (SALL4), octamer-binding transcription factor 3\/4 (OCT3\/4), placental alkaline phosphatase (PLAP), c-kit, and vimentin. The maned wolf had nonspecific and long-standing clinical signs of lethargy, anorexia, and weight loss, and was euthanized because of poor prognosis. At autopsy, the left ovary was effaced by a 12 \u00d7 8 \u00d7 6\u2009cm mass, comprised of anaplastic cells with a mitotic count of 20 mitoses in 10 high power fields. Dysgerminomas from 7 of 13 domestic dogs had nuclear expression of SALL4. Dysgerminomas from the maned wolf and 2 domestic dogs had both nuclear and cytoplasmic expression of SALL4. Cytoplasmic expression of PLAP and OCT3\/4 was present in dysgerminomas from the maned wolf and 3 (PLAP) or 4 (OCT3\/4) domestic dogs. All dysgerminomas expressed vimentin. Membranous c-kit expression was rare in the dysgerminoma from the maned wolf, and variable in dysgerminomas from 4 domestic dogs. A dysgerminoma from a domestic dog had cytoplasmic expression of c-kit. SALL4 is a useful marker to confirm germ cell origin of dysgerminoma in canids.<\/jats:p>","DOI":"10.1177\/10406387211019959","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T16:16:30Z","timestamp":1622304990000},"page":"772-776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of immunohistochemical profiles of ovarian germ cells in dysgerminomas of a captive maned wolf and domestic dogs"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-7428","authenticated-orcid":false,"given":"Rafael B.","family":"Rosa","sequence":"first","affiliation":[{"name":"Setor de Patologia Veterin\u00e1ria, Departamento de Patologia Cl\u00ednica Veterin\u00e1ria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-0038","authenticated-orcid":false,"given":"Matheus V.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Setor de Patologia Veterin\u00e1ria, Departamento de Patologia Cl\u00ednica Veterin\u00e1ria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula R.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Setor de Patologia Veterin\u00e1ria, Departamento de Patologia Cl\u00ednica Veterin\u00e1ria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando F.","family":"Argenta","sequence":"additional","affiliation":[{"name":"Setor de Patologia Veterin\u00e1ria, Departamento de Patologia Cl\u00ednica Veterin\u00e1ria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia","family":"Vielmo","sequence":"additional","affiliation":[{"name":"Setor de Patologia Veterin\u00e1ria, Departamento de Patologia Cl\u00ednica Veterin\u00e1ria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A. 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