{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:40:17Z","timestamp":1777930817837,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>A 9-y-5-mo-old, spayed female, mixed-breed dog with buphthalmia and elevated intraocular pressure in the left eye, consistent with glaucoma, was evaluated. Black-pigmented, slightly elevated tissue with irregular margins was noted on the dorsolateral aspect of the left globe. Ultrasonography detected a mass, later identified as lacrimal gland, adjacent to the globe and the thickened uvea. The surgically removed lacrimal gland was effaced by dense sheets of melanin-laden cells. Within the enucleated globe, numerous melanin-laden cells infiltrated and expanded the rostral two-thirds thickness of the cornea, the entire anterior uvea (iris and ciliary body), and a rostral portion of the choroid. Melanin-laden cells in the left lacrimal gland and globe showed no nuclear atypia or mitotic figures, and reacted to anti-S100 and anti\u2013melan A antibodies by immunohistochemistry. Our final diagnosis was concurrent lacrimal gland melanocytoma and ocular melanocytosis. The trabecular meshwork of the eye was obliterated by melanin-laden cells, which was the likely cause of glaucoma in this patient. To our knowledge, melanocytoma affecting the lacrimal gland has not been reported previously in a non-human mammalian species. Veterinary clinicians are encouraged to include melanocytoma in the differential list when examining an enlarged lacrimal gland.<\/jats:p>","DOI":"10.1177\/10406387211045027","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T09:27:15Z","timestamp":1631525235000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent lacrimal gland melanocytoma and ocular melanocytosis in a dog"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-0097","authenticated-orcid":false,"given":"Ikki","family":"Mitsui","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"MIRU Animal Hospital, Imabari, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"bibr1-10406387211045027","first-page":"159","volume":"6","author":"Andreasen S","year":"2017","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"bibr2-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12009"},{"key":"bibr3-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12273"},{"key":"bibr4-10406387211045027","first-page":"892","volume-title":"Tumors in Domestic Animals","volume":"2017","author":"Dubielzig RR","edition":"5"},{"key":"bibr5-10406387211045027","first-page":"245","volume-title":"Veterinary Ocular Pathology","volume":"2010","author":"Dubielzig RR"},{"key":"bibr6-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.8.1166"},{"key":"bibr7-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818823667"},{"key":"bibr8-10406387211045027","first-page":"88","volume-title":"Tumors in Domestic Animals","volume":"2017","author":"Goldschmidt MH","edition":"5"},{"key":"bibr9-10406387211045027","first-page":"409","volume-title":"Histologic Basis of Ocular Disease in Animals","volume":"2019","author":"Grahn B","edition":"1"},{"key":"bibr10-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-4-353"},{"key":"bibr11-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12489"},{"key":"bibr12-10406387211045027","volume":"7","author":"Matsuo T","year":"2019","journal-title":"J Investig Med High Impact Case Rep"},{"key":"bibr13-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12297"},{"key":"bibr14-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000256"},{"key":"bibr15-10406387211045027","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23193"},{"key":"bibr16-10406387211045027","first-page":"484","volume-title":"Jubb, Kennedy & Palmer\u2019s Pathology of Domestic Animals","volume":"2016","author":"Wilcock BP","edition":"6"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387211045027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387211045027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387211045027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:24:57Z","timestamp":1777681497000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387211045027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/10406387211045027"],"URL":"https:\/\/doi.org\/10.1177\/10406387211045027","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]}}}