{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:40:25Z","timestamp":1777930825285,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Interprovincial Graduate Student Fund"},{"name":"Townsend Equine Health Research Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Inter- and intra-rater variability negatively affects the reliability of various histopathology grading scales used as prognostic aids in human and veterinary medicine. The Kenney\u2013Doig categorization (grading) scale, which is used to associate equine endometrial histologic lesions with prognostic estimation of a broodmare\u2019s reproductive potential, has not been evaluated for inter- or intra-rater variability, to our knowledge. To assess whether the Kenney\u2013Doig system produces reliable results among observers, 8 pathologists, all with American College of Veterinary Pathologists certification, were recruited to blindly categorize the same set of 63 digital equine endometrial biopsy slides as well as to re-evaluate anonymously 21 of 63 of these slides at a later time. Cohen kappa values for pairwise comparison of final Kenney\u2013Doig categories were \u22120.05 to 0.46 (unweighted) and 0.08\u20130.64 (weighted), with an average Light kappa of 0.19 (unweighted) and 0.36 (weighted) across all 8 pathologists, 0.14 (unweighted) and 0.33 (weighted) for pathologists at different institutions, and 0.22 (unweighted) and 0.46 (weighted) for pathologists at the same institution. Intra-class correlations measuring intra-rater agreement were 0.12\u20130.77 with an average of 0.55 for all 8 pathologists. We found that only slight-to-moderate inter-rater agreement and poor-to-good intra-rater agreement was produced by 8 pathologists using the Kenney\u2013Doig scale, suggesting that the system is subject to significant observer variability and care should be taken when communicating Kenney\u2013Doig categories to submitting clinicians with emphasis on the quality of endometrial lesions present instead of the category and associated expected foaling rate.<\/jats:p>","DOI":"10.1177\/10406387211062866","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T23:56:51Z","timestamp":1640822211000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["IIB or not IIB, part 2: assessing inter-rater and intra-rater repeatability of the Kenney\u2013Doig scale in equine endometrial biopsy evaluation"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-6611","authenticated-orcid":false,"given":"Jane","family":"Westendorf","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Wobeser","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasha","family":"Epp","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4320(92)90088-U"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2003.11.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199909000-00014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2003.00013.x"},{"key":"e_1_3_3_6_2","article-title":"Guidelines of the minimum sample size requirements for Cohen\u2019s kappa","volume":"14","author":"Bujang MA","year":"2017","unstructured":"Bujang MA, Baharum N. 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