{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:16:52Z","timestamp":1785431812914,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>A large, firm, multi-cystic mammary gland mass grew slowly over 4\u2009y in a 12-y-old, female Finn\u2013Shetland cross sheep. A diagnosis of epithelial malignancy was suspected following fine-needle aspiration cytology at 30\u2009mo after initial observation. The sheep was euthanized when the flock was downsized 18\u2009mo later. A field postmortem examination revealed a large mammary mass, but an absence of metastases to internal organs. Imprint cytology of the mammary tissue supported a benign proliferative process. Histologically, mammary tissue was obliterated by cystic, tubular, and papillary adenomatous arrangements of mammary epithelium, with an anaplastic component, consistent with mammary carcinoma arising in an adenoma. IHC showed strong nuclear positivity to the antibody against progesterone receptor and minimal positivity to the antibody against estrogen receptor alpha expression. Intrinsic subtyping for basal or luminal epithelial origin was attempted through adaptation of companion animal IHC classification panels; high- and low-molecular-weight cytokeratins (CK5, CK8, CK18) failed to stain, but p63 expression for basal epithelium was positive.<\/jats:p>","DOI":"10.1177\/1040638721993061","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T07:24:18Z","timestamp":1613114658000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Mammary carcinoma arising in an adenoma in a ewe"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-4816","authenticated-orcid":false,"given":"Shelley J.","family":"Newman","sequence":"first","affiliation":[{"name":"Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"bibr1-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300222"},{"key":"bibr2-1040638721993061","first-page":"536","volume":"163","author":"Aydogan A","year":"2012","journal-title":"Revue Med Vet"},{"key":"bibr3-1040638721993061","first-page":"205","volume":"49","author":"Bastianello SS","year":"1982","journal-title":"Onderstepoort J Vet Res"},{"key":"bibr4-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818763711"},{"key":"bibr5-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.4.933"},{"key":"bibr6-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1021\/jf021114s"},{"key":"bibr7-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2062-y"},{"key":"bibr8-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1992.35695"},{"key":"bibr9-1040638721993061","first-page":"163","volume":"12","author":"Desfoulian O","year":"2011","journal-title":"Iran J Vet Res"},{"key":"bibr10-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilv044"},{"key":"bibr11-1040638721993061","doi-asserted-by":"crossref","first-page":"e0221776","DOI":"10.1371\/journal.pone.0221776","volume":"14","author":"Ferriera D","year":"2019","journal-title":"PLoS One"},{"key":"bibr12-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2005.tb13299.x"},{"key":"bibr13-1040638721993061","first-page":"723","volume-title":"Tumors in Domestic Animals","author":"Goldschmidt MH","year":"2017","edition":"5"},{"key":"bibr14-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2009.12.013"},{"key":"bibr15-1040638721993061","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2007.8.4.423"},{"key":"bibr16-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-018-0417-1"},{"key":"bibr17-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812471544"},{"key":"bibr18-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-3-320"},{"key":"bibr19-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1177\/104063871002200630"},{"key":"bibr20-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2005.02.002"},{"key":"bibr21-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2015.08.008"},{"key":"bibr22-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-3-239"},{"key":"bibr23-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12597"},{"key":"bibr24-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01159"},{"key":"bibr25-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1980.tb02536.x"},{"key":"bibr26-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1007\/BF01831473"},{"key":"bibr27-1040638721993061","first-page":"1249","volume":"43","author":"Schneider R","year":"1969","journal-title":"J Natl Cancer Inst"},{"key":"bibr28-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(92)90044-G"},{"key":"bibr29-1040638721993061","doi-asserted-by":"publisher","DOI":"10.1177\/104063870701900316"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638721993061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638721993061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638721993061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:25:19Z","timestamp":1777681519000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638721993061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/1040638721993061"],"URL":"https:\/\/doi.org\/10.1177\/1040638721993061","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,12]]}}}