{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:13:25Z","timestamp":1783538005568,"version":"3.55.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>A 4-y-old, female mixed-breed dog was presented to the Ontario Veterinary College for further evaluation of multiple pulmonary and hepatic masses, intrathoracic lymphadenitis, and recent development of a pyogranulomatous pleural effusion. Along with other comprehensive tests, a thoracic lymph node biopsy was performed, and Mycobacterium tuberculosis complex infection was confirmed by real-time PCR. The dog\u2019s condition declined post-operatively, and euthanasia was elected. Postmortem examination confirmed severe granulomatous pneumonia, hepatitis, intrathoracic and intraabdominal lymphadenitis, omentitis, and nephritis. Line-probe assays performed on samples collected postmortem confirmed the species as M. tuberculosis. 24-loci MIRU-VNTR genotyping, spoligotyping, and whole-genome sequencing revealed relations to known human isolates, but no epidemiologic link to these cases was investigated. Given the concern for potential human exposure during this animal\u2019s disease course, a public health investigation was initiated; 45 individuals were tested for M. tuberculosis exposure, and no subsequent human infections related to this animal were identified. Our case highlights the need for more readily available, minimally invasive testing for the diagnosis of canine mycobacteriosis, and highlights the ability of canid species to act as potential contributors to the epidemiology of M. tuberculosis infections.<\/jats:p>","DOI":"10.1177\/10406387221074706","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T06:19:22Z","timestamp":1643091562000},"page":"292-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic and public health investigation of\n                    <i>Mycobacterium tuberculosis<\/i>\n                    infection in a dog in Ontario, Canada"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-6654","authenticated-orcid":false,"given":"Luke A. J.","family":"Haydock","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C. G.","family":"Abrams-Ogg","sequence":"additional","affiliation":[{"name":"Health Sciences Centre, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-1937","authenticated-orcid":false,"given":"J. Scott","family":"Weese","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, and Centre for Public Health and Zoonoses, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Central Toronto Veterinary Referral Clinic, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Clifford","sequence":"additional","affiliation":[{"name":"Toronto Public Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Toronto Public Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Rea","sequence":"additional","affiliation":[{"name":"Toronto Public Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances B.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Public Health Ontario, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Duncan","sequence":"additional","affiliation":[{"name":"Public Health Ontario, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Andrievskaia","sequence":"additional","affiliation":[{"name":"Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Savic","sequence":"additional","affiliation":[{"name":"Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durda","family":"Slavic","sequence":"additional","affiliation":[{"name":"Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Health Sciences Centre, University of Guelph, Guelph, Ontario, Canada, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara L.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Health Sciences Centre, University of Guelph, Guelph, Ontario, Canada, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline 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