{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:49:26Z","timestamp":1790952566012,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Here we characterize the neuroanatomic distribution, neuropathology, and immunophenotype of 10 cases of primary nervous system lymphoma in cats. Cases were retrospectively searched from 2 academic institutions. Selected cases were reviewed and subjected to immunohistochemistry (IHC) for CD3, CD20, and Pax5. The mean age of affected cats was 9.1 y, and no sex or breed predilection was observed. The most common clinical sign was ataxia (8 cases). Gross changes reported in 8 cases consisted of white-to-tan masses (7 cases) or swelling (1 case) within the neuroparenchyma (5 cases) or epidural spaces (3 cases). Histologically, intraparenchymal lymphomas occurred in the gray and white matter or perivascular spaces (7 cases); extraparenchymal lymphomas (6 cases) consisted of neoplastic cell infiltration of the perivascular spaces in the leptomeninges, choroid plexus, or epidural spaces. Nerve lymphomas were diffusely infiltrative. Tumors occurred in the brain (4 cases), spinal cord and nerves (3 cases), spinal cord (2 cases), and brain, spinal cord, and nerves (1 case). IHC was consistent with a B-cell lymphoma in 5 cases and with a T-cell lymphoma in 5 cases.<\/jats:p>","DOI":"10.1177\/10406387221090281","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T08:53:42Z","timestamp":1650444822000},"page":"712-717","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Primary nervous system lymphoma in cats"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2836","authenticated-orcid":false,"given":"Daniel R.","family":"Rissi","sequence":"first","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, Department of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany J.","family":"McHale","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory, Small Animal Medicine and Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Miller","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Georgia, Athens, GA, USA"},{"name":"Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"bibr1-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-5-2-104"},{"key":"bibr2-10406387221090281","first-page":"602","volume":"54","author":"Guil-Luna S","year":"2013","journal-title":"Can Vet J"},{"key":"bibr3-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45-1-54"},{"key":"bibr4-10406387221090281","author":"Koestner A","year":"1999","journal-title":"Armed Forces Institute of Pathology"},{"key":"bibr5-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12535"},{"key":"bibr6-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.09.007"},{"key":"bibr7-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"bibr8-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.07.013"},{"key":"bibr9-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712460674"},{"key":"bibr10-10406387221090281","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.2.237"},{"key":"bibr11-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02632.x"},{"key":"bibr12-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb00500.x"},{"key":"bibr13-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.09.003"},{"key":"bibr14-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16689506"},{"key":"bibr15-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.13-0260"},{"key":"bibr16-10406387221090281","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.200.03.373"},{"key":"bibr17-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2009.00813.x"},{"key":"bibr18-10406387221090281","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb00158.x"},{"key":"bibr19-10406387221090281","first-page":"850","volume-title":"J Vet Intern Med","volume":"17","author":"Troxel MT","year":"2003"},{"key":"bibr20-10406387221090281","first-page":"102","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","volume":"3","author":"Valli VEO","edition":"6"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387221090281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387221090281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387221090281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:25:35Z","timestamp":1777681535000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387221090281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/10406387221090281"],"URL":"https:\/\/doi.org\/10.1177\/10406387221090281","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]}}}