{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:02Z","timestamp":1777930862537,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Tyzzer disease (TD) is a highly fatal condition of animals caused by Clostridium piliforme and characterized pathologically by enteritis, hepatitis, myocarditis, and occasionally encephalitis. Cutaneous lesions have been reported only rarely in animals with TD, and infection of the nervous system has not been described in cats, to our knowledge. We describe here neurologic and cutaneous infection by C. piliforme in a shelter kitten with systemic manifestations of TD and coinfection with feline panleukopenia virus. Systemic lesions included necrotizing typhlocolitis, hepatitis, myocarditis, and myeloencephalitis. The cutaneous lesions consisted of intraepidermal pustular dermatitis and folliculitis, with necrosis of keratinocytes and ulceration. Clostridial bacilli were identified within the cytoplasm of keratinocytes by fluorescence in situ hybridization, and a PCR assay was positive for C. piliforme. C. piliforme can infect keratinocytes leading to cutaneous lesions in cats with the location suggesting direct contact with contaminated feces as a route of infection.<\/jats:p>","DOI":"10.1177\/10406387231159931","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T04:26:21Z","timestamp":1678422381000},"page":"322-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurologic and cutaneous infection by\n                    <i>Clostridium piliforme<\/i>\n                    in a kitten with systemic Tyzzer disease"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-0406","authenticated-orcid":false,"given":"Eric S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia Animal, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-3867","authenticated-orcid":false,"given":"Cintia R. R.","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia Animal, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel O.","family":"Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia Animal, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa G. A.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia Animal, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael G. C.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia Animal, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Pierezan","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1rias, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato L.","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1rias, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco C. F.","family":"Lobato","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Preventiva, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo O. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Preventiva, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-281X","authenticated-orcid":false,"given":"Paula R.","family":"Giaretta","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"bibr1-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(77)90031-1"},{"key":"bibr2-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb00725.x"},{"key":"bibr3-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-5-765"},{"key":"bibr4-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-43-2-314"},{"key":"bibr5-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1177\/10406387231154554"},{"key":"bibr6-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1177\/10406387211031213"},{"key":"bibr7-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1354\/vp.46-1-151"},{"key":"bibr8-10406387231159931","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1805.04057"},{"key":"bibr9-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1354\/vp.36-6-613"},{"key":"bibr10-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1177\/1040638711425594"},{"key":"bibr11-10406387231159931","doi-asserted-by":"publisher","DOI":"10.7589\/2017-02-041"},{"key":"bibr12-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1177\/1040638719886567"},{"key":"bibr13-10406387231159931","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715593600"},{"key":"bibr14-10406387231159931","doi-asserted-by":"crossref","unstructured":"Percy DH, Barthold SW. 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