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Clinically, these cases were characterized by rapid onset of hyperthermia followed by death after kidding. On postmortem examination, the uteri appeared to be necrotic and were hemorrhagic and edematous. Microscopically, the uteri had diffuse coagulative necrosis, edema, hemorrhage, and fibrinous thrombi with intralesional gram-positive rods. Clostridium perfringens was isolated from 7 of 9 uterine samples cultured, and C. perfringens, C. septicum, C. novyi, or C. chauvoei were demonstrated by immunohistochemistry (IHC) in the 5 cases examined. IHC for Paeniclostridium sordellii was negative in all 5 cases. PCR performed on 3 of the C. perfringens isolates was positive for alpha toxin and perfringolysin, identifying these isolates as type A. Clostridial infection should be considered in cases of postpartum gangrenous metritis of does.<\/jats:p>","DOI":"10.1177\/10406387231161508","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T08:02:32Z","timestamp":1678694552000},"page":"266-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Postpartum clostridial gangrenous metritis in 12 dairy goats in France"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-951X","authenticated-orcid":false,"given":"La\u00ebtitia","family":"Dorso","sequence":"first","affiliation":[{"name":"Oniris, INRAE (National Research Institute for Agriculture, Food and the Environment), BIOEPAR (Biology, Epidemiology and Risk Analysis in Animal Health), Nantes, France"},{"name":"Oniris, CHUV (University Veterinary Hospital), Nantes, 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