{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:12Z","timestamp":1787019012043,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Distinct patterns of local infiltration are a common feature of canine oligodendroglioma and astrocytoma, and typically involve the surrounding neuroparenchyma, ventricles, or leptomeninges. Infiltration of adjacent extraneural sites is rare and has not been well documented in veterinary medicine. Here we describe 6 canine gliomas with cribriform plate involvement (compression or infiltration) and caudal nasal invasion confirmed by neuroimaging, autopsy, and\/or histology. All affected dogs were adults (9\u201312-y-old), and 3 were brachycephalic. Clinical signs were associated with the brain tumor, with no respiratory signs reported. Magnetic resonance imaging in 2 patients revealed a rostral intraparenchymal telencephalic mass with extension into the cribriform plate. All dogs were euthanized. Gross changes consisted of poorly demarcated, white or pale-yellow, soft, and, in oligodendrogliomas, gelatinous, intraparenchymal masses that expanded the rostral portions of the telencephalon and adhered firmly to the ethmoid bone and cribriform plate. Gliomas were classified as high-grade oligodendrogliomas (4 cases) and high-grade astrocytomas (2 cases) based on histology and immunohistochemistry for OLIG2 and GFAP. In all cases, there was evidence of cribriform plate invasion and, in one case, additional invasion of the caudal nasal cavity.<\/jats:p>","DOI":"10.1177\/10406387231195291","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T03:41:56Z","timestamp":1692762116000},"page":"800-805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Glioma with cribriform plate involvement in 6 dogs"],"prefix":"10.1177","volume":"35","author":[{"given":"Vicente A. A.","family":"Reyes","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Howerth","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel","family":"Blas-Machado","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"},{"name":"Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo P.","family":"Pavarini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas T.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2836","authenticated-orcid":false,"given":"Daniel R.","family":"Rissi","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"},{"name":"Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"bibr1-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16199"},{"key":"bibr2-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly085"},{"key":"bibr3-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813476056"},{"key":"bibr4-10406387231195291","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01151"},{"key":"bibr5-10406387231195291","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.33.312"},{"key":"bibr6-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17-0652"},{"key":"bibr7-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2019-000958"},{"key":"bibr8-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12506"},{"key":"bibr9-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1177\/1040638716673127"},{"key":"bibr10-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715584619"},{"key":"bibr11-10406387231195291","doi-asserted-by":"publisher","DOI":"10.1080\/02688690500081164"},{"key":"bibr12-10406387231195291","first-page":"252","volume-title":"Dyce, 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