{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:20Z","timestamp":1777930880206,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    An 11-y-old hembra alpaca was admitted because of cerebellar and vestibular signs, dysphagia, and aspiration pneumonia; without clinical improvement following empirical therapy, the patient was euthanized. On autopsy, a neoplasm was found incorporating the right vestibulocochlear nerve at the level of the acoustic meatus. Histologically, the mass was composed of a multiphasic primitive cell population associated with a dense fibrous stroma and enveloping a remnant ganglion and nerve bundles. Patterns included dense ribbons and cords of embryonal neuroepithelial cells admixed with loosely defined interlacing spindle cells. The embryonal cells had angular cell profiles with variable amounts of lightly basophilic cytoplasm, ovoid-to-irregular nuclei, and an open chromatin pattern with a typically inapparent nucleolus. Necrosis was not evident, and there was 1 mitotic figure per 2.37\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    . The entire mass was infiltrated by small numbers of lymphocytes and plasma cells. Immunohistochemistry (IHC) revealed strong and diffuse cytoplasmic immunolabeling for vimentin, microtubule-associated protein-2, protein gene product 9.5, and synaptophysin; ~50% immunolabeling for cytokeratin AE1\/3; sporadic OLIG2 and S100 immunolabeling; and absent glial fibrillary acidic protein immunolabeling. Based on the histologic pattern and the IHC results, our diagnosis was a poorly differentiated embryonal tumor with ependymal differentiation associated with the vestibulocochlear nerve.\n                  <\/jats:p>","DOI":"10.1177\/10406387231195611","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:31:26Z","timestamp":1693211486000},"page":"777-781","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Intracranial embryonal neoplasm in an alpaca"],"prefix":"10.1177","volume":"35","author":[{"given":"Alexandra","family":"Fielding","sequence":"first","affiliation":[{"name":"Hospital for Large Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian","family":"Minuto","sequence":"additional","affiliation":[{"name":"Hospital for Large Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Mazan","sequence":"additional","affiliation":[{"name":"Hospital for Large Animals, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-5581","authenticated-orcid":false,"given":"Andrew D.","family":"Miller","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University, Ithaca, NY, USA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-4816","authenticated-orcid":false,"given":"Shelley J.","family":"Newman","sequence":"additional","affiliation":[{"name":"Newman Specialty VetPath, Hicksville, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"bibr1-10406387231195611","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.743498"},{"key":"bibr2-10406387231195611","doi-asserted-by":"publisher","DOI":"10.12968\/live.2016.21.5.308"},{"key":"bibr3-10406387231195611","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.02.006"},{"key":"bibr4-10406387231195611","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2012.00404.x"},{"key":"bibr5-10406387231195611","doi-asserted-by":"publisher","DOI":"10.1177\/10935266211018554"},{"key":"bibr6-10406387231195611","first-page":"531","volume-title":"De Lahunta\u2019s Veterinary Neuroanatomy and Clinical Neurology","volume":"2021","author":"de Lahunta A","edition":"5"},{"key":"bibr7-10406387231195611","first-page":"1232","volume":"52","author":"Gains MJ","year":"2011","journal-title":"Can Vet 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