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Both cell populations gradually changed from low-grade morphologic features to highly anaplastic ones. Immunohistochemically, the eosinophilic tumor cells were positive for cytokeratin 8, a useful marker for luminal epithelial cells. In contrast, the clear tumor cells expressed several myoepithelial markers, including \u03b1-smooth muscle actin, p63, and cytokeratin 14. Based on these histologic and immunohistochemical characteristics, we diagnosed this apocrine sweat gland tumor as a carcinoma-and-malignant myoepithelioma with high-grade transformation of both luminal and myoepithelial cells. Our case may be a helpful reference for the histogenesis of carcinoma-and-malignant myoepithelioma, in which both the luminal epithelial and myoepithelial components are malignant.<\/jats:p>","DOI":"10.1177\/10406387231202529","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:20:35Z","timestamp":1696299635000},"page":"789-794","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Apocrine carcinoma-and-malignant myoepithelioma in a dog: a case of simultaneous malignant progression of both luminal epithelium and myoepithelium"],"prefix":"10.1177","volume":"35","author":[{"given":"Kana","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Laboratory of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya Evan","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan"},{"name":"Fujifilm Vet Systems, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0353-3668","authenticated-orcid":false,"given":"Masaki","family":"Michishita","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimimasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6498-4529","authenticated-orcid":false,"given":"Hisashi","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University (NVLU), Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"bibr1-10406387231202529","first-page":"301","volume-title":"Diagnostic Histopathology of Tumors","volume":"1","author":"Cheuk W","year":"2021","edition":"5"},{"key":"bibr2-10406387231202529","unstructured":"El-Naggar AK, et al WHO Classification of Head & Neck Tumours. 4th ed. 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