{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:21Z","timestamp":1777930881704,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Center for Companion Animal Studies at Colorado State University"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Thyrotropin-releasing hormone (TRH) stimulation can be used as a test of thyroid function and pituitary thyrotropin (thyroid-stimulating hormone, TSH) reserve, but optimal stimulation testing protocols in cats are unreported. We randomly divided 6 healthy young adult cats into 3 groups of 2 and administered 3 different intravenous doses of TRH (0.01, 0.05, 0.1\u2009mg\/kg) at weekly intervals in our crossover study. Serum TSH and thyroxine (T4) concentrations were measured using chemiluminescent immunoassay before, and at 30 and 60\u2009min after, TRH administration. All cats were monitored for 4\u2009h post-TRH administration for side effects. All 3 TRH doses induced significant TSH (0.01\u2009mg\/kg, p\u2009 =\u20090.001; 0.05\u2009mg\/kg, p\u2009=\u20090.002; 0.1\u2009mg\/kg, p\u2009 =\u20090.006) and total T4 (0.01\u2009mg\/kg, p\u2009 =\u20090.008; 0.05\u2009mg\/kg, p\u2009=\u20090.006; 0.1\u2009mg\/kg, p\u2009 =\u20090.001) responses. Lower TRH doses (0.01 and 0.05\u2009mg\/kg) caused fewer side effects (1 of 6 cats) than did the highest dose (3 of 6 cats), and may be safer in cats than the previously reported higher dose (0.1\u2009mg\/kg) of TRH. Our results do not support the use of maropitant to prevent side effects of a TRH stimulation test in cats.<\/jats:p>","DOI":"10.1177\/10406387231212816","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:45:35Z","timestamp":1700095535000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Total thyroxine and thyroid-stimulating hormone responses of healthy cats to different doses of thyrotropin-releasing hormone"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4300-8534","authenticated-orcid":false,"given":"Petra","family":"\u010cern\u00e1","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markos","family":"Antonakakis","sequence":"additional","affiliation":[{"name":"Department 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Lappin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"bibr1-10406387231212816","first-page":"1323","volume":"46","author":"Evinger JV","year":"1985","journal-title":"Am J Vet Res"},{"key":"bibr2-10406387231212816","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.903"},{"key":"bibr3-10406387231212816","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16080"},{"key":"bibr4-10406387231212816","first-page":"101","volume-title":"Feline Endocrinology","volume":"2019","author":"Ferguson 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