{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:27Z","timestamp":1777930887770,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"California Animal Health and Food Safety Laboratory, UCDavis"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>A flock of 48 sheep in Argentina grazing on a pasture of hybrid Urochloa (formerly Brachiaria) Mulato II ( Urochloa ruziziensis\u2009\u00d7\u2009 Urochloa decumbens\u2009\u00d7\u2009 Urochloa brizantha) developed facial dermatitis, severe jaundice, and weakness after brief physical activity. Blood biochemistry of 3 animals revealed azotemia, elevated aspartate aminotransferase activity, and increased direct, indirect, and total bilirubin concentrations. The urine was markedly turbid and contained large concentrations of bile pigments and protein. At autopsy of 2 animals, there was severe jaundice and subcutaneous submandibular edema. The livers were enlarged, intensely yellow, and had a marked acinar pattern. Gallbladders were distended, and the kidneys were diffusely dark in one animal and yellow-green in the other. Microscopically, there was lymphoplasmacytic and histiocytic cholangiohepatitis with abundant crystals in the lumen of bile ducts and in the cytoplasm of macrophages. The proximal and distal convoluted renal tubules had protein casts in their lumens, and crystals were observed in the lumen and epithelial cells. Lectin histochemistry showed strong affinity for Arachis hypogaea agglutinin in hepatic macrophages. In the one sheep that was tested for heavy metals, copper concentrations in the liver and kidney were within the RIs. Despite the immediate change of pasture, morbidity and mortality were 100% within 3\u2009mo. The association between the consumption of this pasture, and the clinical, biochemical, pathology, and lectin histochemistry findings confirmed intoxication with Urochloa hybrid Mulato II. To our knowledge, intoxication by this hybrid of Urochloa has not been reported previously.<\/jats:p>","DOI":"10.1177\/10406387241228905","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T04:25:35Z","timestamp":1708057535000},"page":"262-268","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic and renal lesions in sheep intoxicated with\n                    <i>Urochloa<\/i>\n                    hybrid Mulato II in Argentina"],"prefix":"10.1177","volume":"36","author":[{"given":"Ra\u00fal E.","family":"Marin","sequence":"first","affiliation":[{"name":"Faculty of Agricultural Sciences, National University of Jujuy, Jujuy, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo J.","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, National University of La Plata, La Plata, Argentina"},{"name":"National Council of Scientific Research, Buenos Aires, CONICET, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-7785","authenticated-orcid":false,"given":"Franklin","family":"Riet-Correa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-1878","authenticated-orcid":false,"given":"Francisco A.","family":"Uzal","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino Laboratory, School of Veterinary Medicine, University of California\u2013Davis, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"bibr1-10406387241228905","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2010000900006"},{"key":"bibr2-10406387241228905","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022010707704"},{"key":"bibr3-10406387241228905","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-4488(03)00195-0"},{"key":"bibr4-10406387241228905","first-page":"118","volume-title":"Poisoning by Plants, Mycotoxins and Related Toxins","volume":"2011","author":"Barbosa-Ferreira M"},{"issue":"4","key":"bibr5-10406387241228905","first-page":"580","volume":"18","author":"Barbosa-Ferreira M","year":"2011","journal-title":"Vet Zootec"},{"key":"bibr6-10406387241228905","first-page":"13","volume":"24","author":"Brum KB","year":"2004","journal-title":"Pesq Vet Bras"},{"key":"bibr7-10406387241228905","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2007000100007"},{"key":"bibr8-10406387241228905","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-84782008005000034"},{"key":"bibr9-10406387241228905","unstructured":"Burghi V, et al. Gram\u00edneas forrajeras para el subtr\u00f3pico y el semi\u00e1rido central de la Argentina [Forage grasses for the subtropics and central semiarid Argentina]. INTA, 2014. 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