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In 2020, 49 autopsies from early rabbit deaths in a colony used for medical device biocompatibility studies were submitted for microscopic examination. Of the 49 rabbits, 26 had histologic changes consistent with CCM. No common stressor for CCM was determined in affected rabbits. Animals were generally male, were 12\u201316-wk-old, and were found dead or had bloating, lethargy, and\/or diarrhea. Those observed with clinical signs were euthanized and autopsied per the organization\u2019s standard operating procedures. Heart lesions consisted of various degrees of apical subendocardial myocardial degeneration and necrosis. 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