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CBC revealed mild lymphopenia; serum biochemistry findings were of increased gamma-glutamyl transferase and creatine kinase activities, hyperferremia, hyperglycemia, hypomagnesemia, and hypokalemia. Abdominocentesis was compatible with low-protein transudate. Due to the progression and duration of clinical signs, the owner elected euthanasia. Postmortem examination and histopathology confirmed a cholangiocarcinoma. The neoplastic cells were arranged in large cysts containing lakes of mucin that comprised 90% of the tumor volume; thus, a mucinous variant was determined. The neoplastic cells had strong cytoplasmic immunolabeling for cytokeratin 19 and lacked immunolabeling for hepatocyte paraffin 1, supporting bile duct origin. Cholangiocarcinomas are infrequent tumors in horses with nonspecific and slow progressive clinical signs, including recurrent colic. Mucinous cholangiocarcinomas are seldom reported in veterinary medicine and, to our knowledge, have not been reported previously in horses.<\/jats:p>","DOI":"10.1177\/10406387241245775","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:50:05Z","timestamp":1713592205000},"page":"547-553","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse case report and literature review of cholangiocarcinoma in horses"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-3774","authenticated-orcid":false,"given":"Daniel Felipe","family":"Barrantes Murillo","sequence":"first","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Cattley","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"},{"name":"Current addresses: Gastrointestinal Laboratory, School of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Withers","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Towns","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pfeifle","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"},{"name":"Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Wooldridge","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L. 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