{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:41Z","timestamp":1777930901686,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Synovial myxoma, a rare joint tumor in dogs, has traditionally been considered benign, acknowledging that local invasion into regional tissues including bone may be present. Given the diagnostic challenges in distinguishing synovial myxoma from other joint lesions through clinical features and diagnostic imaging, definitive diagnosis relies on characteristic gross and histologic features. Within the inner surface of the joint capsule, synovial myxomas form nodules of stellate-to-spindle cells within abundant myxomatous matrix. We present here 2 cases of synovial myxoma with metastasis to regional lymph nodes and compare these 2 cases to 3 cases without evidence of lymph node metastasis. Aside from lymphovascular invasion in one case with metastasis, there were no overt histologic features of the primary tumor to suggest aggressive biologic behavior. The finding of lymph node metastasis warrants reconsideration of the term \u201csynovial myxoma\u201d for this neoplasm. We suggest the term \u201csynovial myxosarcoma,\u201d considering that histologic features of the primary tumor do not predict biologic behavior. Our case series highlights the importance of lymph node sampling in suspected synovial myxosarcoma cases as well as thorough histologic examination, emphasizing careful evaluation for lymphovascular invasion.<\/jats:p>","DOI":"10.1177\/10406387241257254","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T06:38:32Z","timestamp":1717396712000},"page":"874-878","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synovial myxoma or myxosarcoma? Lymph node metastasis in 2 dogs"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9247-9302","authenticated-orcid":false,"given":"Imaine","family":"Glahn","sequence":"first","affiliation":[{"name":"University of Veterinary Medicine Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taryn A.","family":"Donovan","sequence":"additional","affiliation":[{"name":"The Schwarzman Animal Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2402-9997","authenticated-orcid":false,"given":"Christof A.","family":"Bertram","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"bibr1-10406387241257254","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2000.0451"},{"key":"bibr2-10406387241257254","unstructured":"Craig L. Wednesday Slide Conference 2016\u20132017: conference 21, case I: 12B2212 (JPC 4050655). Department of Defense, Veterinary Pathology Residency Program, Joint Pathology Center, March 2017 31:1\u20136. https:\/\/www.askjpc.org\/wsco\/wsc\/wsc16\/16WSC21.pdf"},{"key":"bibr3-10406387241257254","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-66"},{"key":"bibr4-10406387241257254","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810369903"},{"key":"bibr5-10406387241257254","first-page":"337","volume-title":"Tumors in Domestic Animals","volume":"2016","author":"Craig LE","edition":"5"},{"key":"bibr6-10406387241257254","first-page":"257","volume":"30","author":"Griffon DJ","year":"1994","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr7-10406387241257254","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03002.x"},{"key":"bibr8-10406387241257254","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0207"},{"key":"bibr9-10406387241257254","doi-asserted-by":"publisher","DOI":"10.1177\/03009858211013712"},{"key":"bibr10-10406387241257254","unstructured":"Moore FM, et al. Lymphovascular Invasion Guideline, version LVI 2.0 [Internet]. 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