{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:10Z","timestamp":1787019010906,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Copper is a trace element that plays an essential role in neurodevelopment and neurologic function. Acquired copper deficiency has a range of neurologic manifestations, with myelopathy being the most common association. We describe here the clinical, radiologic, histopathologic, and toxicologic findings of a rabbit with malnutrition, neurodegeneration, and suspected copper deficiency. A stray, adult female dwarf rabbit cross ( Oryctolagus cuniculus) in poor body condition developed ataxia and pelvic limb weakness progressing to lateral recumbency and urine retention. The clinical findings suggested multifocal brainstem disease with right-sided central vestibular involvement; however, microscopic examination identified thoracic and lumbosacral spinal cord myelopathy. Differentials for the spinal cord changes included neurodegenerative disease, nutritional deficiency, neurotoxin, trauma to the lumbosacral region, and ischemia. Hepatic copper levels were suboptimal at 18\u2009ppm dry weight (RI: 24\u2013150\u2009ppm dry weight). While speculative, copper-deficiency myelopathy is a treatable cause of non-compressive myelopathy that may occur in this species.<\/jats:p>","DOI":"10.1177\/10406387241258461","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:29:22Z","timestamp":1722842962000},"page":"765-770","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurodegeneration in a domestic rabbit with severe malnourishment and low hepatic copper"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8085-4169","authenticated-orcid":false,"given":"Katherine D.","family":"Watson","sequence":"first","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, Davis branch, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gardhouse","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Sanchez-Migallon","family":"Guzman","sequence":"additional","affiliation":[{"name":"Medicine and Epidemiology, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Poppenga","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, Davis branch, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chai-Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Surgical and Radiological Sciences, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Phillips","sequence":"additional","affiliation":[{"name":"Surgical and Radiological Sciences, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Kol","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Woolard","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"bibr1-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/51.2.295"},{"key":"bibr2-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1177\/030098587801500204"},{"key":"bibr3-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114575000293"},{"key":"bibr4-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92314-0"},{"key":"bibr5-10406387241258461","first-page":"227","volume":"4","author":"Dionyssiotis Y","year":"2012","journal-title":"J Clin Med Res"},{"key":"bibr6-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1080\/00015128309435355"},{"key":"bibr7-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12020"},{"key":"bibr8-10406387241258461","first-page":"2112","volume":"27","author":"Goodman BP","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"bibr9-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0256"},{"key":"bibr10-10406387241258461","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239259"},{"key":"bibr11-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1933.tb00340.x"},{"key":"bibr12-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19700010"},{"key":"bibr13-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/87.4.385"},{"key":"bibr14-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5511-x"},{"key":"bibr15-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/49.4.639"},{"key":"bibr16-10406387241258461","doi-asserted-by":"publisher","DOI":"10.4065\/81.10.1371"},{"key":"bibr17-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1322583"},{"key":"bibr18-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132644.52613.FA"},{"key":"bibr19-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0428-x"},{"key":"bibr20-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-007-0014-z"},{"key":"bibr21-10406387241258461","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2621.2002.00640.x"},{"key":"bibr22-10406387241258461","unstructured":"Meyer RD, et al. 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