{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:46Z","timestamp":1777930906453,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Cerebellar granule cell layer conglutination is a tissue artifact associated with postmortem autolysis that causes cerebellar granule cell changes once thought to be caused by degeneration and necrosis. Granule cell layer conglutination has been reported mainly in humans and cattle and rarely in other animal species, but its frequency remains vastly unknown in veterinary medicine, mostly because this postmortem change is typically not recorded in autopsy reports. Pathology trainees should be aware of autolytic tissue changes that may mimic pathologic changes in the CNS, particularly when those changes are highly selective for a specific cell population within the cerebellar cortex. Here we provide a brief historical perspective on the evolution of cerebellar granule cell layer conglutination from \u201cenzootic cerebellar necrosis,\u201d a presumed necrotic lesion affecting granule neurons in humans and cattle, to a tissue change associated with postmortem autolysis and increased tissue acidity in the cerebellum. We also provide an update on the animal species in which cerebellar granule cell layer conglutination has been observed during our diagnostic pathology routine.<\/jats:p>","DOI":"10.1177\/10406387241270024","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T03:29:53Z","timestamp":1723865393000},"page":"933-936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The artifact of cerebellar granule cell layer conglutination in veterinary medicine: a brief historical perspective and review"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2836","authenticated-orcid":false,"given":"Daniel R.","family":"Rissi","sequence":"first","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3479","authenticated-orcid":false,"given":"Ricardo E.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio S. L.","family":"Barros","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Anatomia Patol\u00f3gica, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"bibr1-10406387241270024","doi-asserted-by":"publisher","DOI":"10.1007\/BF00684537"},{"key":"bibr2-10406387241270024","first-page":"191","volume-title":"Handbuch der Speziellen Pathologischen Anatomie de Haustiere","author":"Fankhauser R","year":"1968"},{"key":"bibr3-10406387241270024","first-page":"616","volume-title":"Histology for Pathologists","volume":"2020","author":"Fuller GN","edition":"5"},{"key":"bibr4-10406387241270024","first-page":"156","volume":"7","author":"Goto M","year":"1959","journal-title":"Jpn J Vet Res"},{"key":"bibr5-10406387241270024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.11.002"},{"key":"bibr6-10406387241270024","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195910000-00013"},{"key":"bibr7-10406387241270024","first-page":"1181","volume-title":"Cienc Rural","volume":"38","author":"Rech RR","year":"2008"},{"key":"bibr8-10406387241270024","volume-title":"Veterinary Neuropathology","author":"Summers BA","year":"1995"},{"key":"bibr9-10406387241270024","first-page":"1","volume-title":"Greenfield\u2019s Neuropathology","volume":"1","author":"Vinters HV","year":"2015","edition":"9"},{"key":"bibr10-10406387241270024","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812450719"},{"key":"bibr11-10406387241270024","first-page":"126","volume":"7","author":"Yamagiwa S","year":"1959","journal-title":"Jpn J Vet Res"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387241270024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387241270024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387241270024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:27:44Z","timestamp":1777681664000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387241270024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,17]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/10406387241270024"],"URL":"https:\/\/doi.org\/10.1177\/10406387241270024","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,17]]}}}