{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:46Z","timestamp":1777930906955,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Schwannosis is a rare, non-neoplastic, perivascular proliferation of aberrant Schwann cells within the CNS with simultaneous partial myelination of axons. A single report exists in veterinary medicine of schwannosis in the spinal cord of 3 foals and 1 calf. Here we describe a case of schwannosis in the brain of a 1-d-old Holstein-Friesian calf, submitted for autopsy due to arthrogryposis and premature death, with no other gross abnormalities observed. Histologically, the brain had multifocal, mainly perivascular, spindle-cell proliferations within the white matter of the medulla oblongata and focally within the gray matter of the midbrain. These cells immunolabeled with periaxin, myelin protein zero, SOX10, S100, and equivocally for vimentin, indicating Schwann cell origin. No changes were identified within other organs. Ancillary tests did not support an infectious etiology. Schwannosis should be considered as a differential diagnosis when investigating cases of arthrogryposis in calves with negative ancillary tests for infectious conditions.<\/jats:p>","DOI":"10.1177\/10406387241283161","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T03:08:01Z","timestamp":1727924881000},"page":"160-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Schwannosis in the brain of a neonatal calf"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0219-8818","authenticated-orcid":false,"given":"Diana","family":"Bochynska","sequence":"first","affiliation":[{"name":"Ross University School of Veterinary Medicine, St Kitts and Nevis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and the Marine Central Veterinary Research Laboratory\u2013Backweston Campus, Kilkenny, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Toland","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and the Marine Central Veterinary Research Laboratory\u2013Backweston Campus, Kilkenny, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Alina","family":"Demeter","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, Cornell University, College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"bibr1-10406387241283161","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2000.17.781"},{"key":"bibr2-10406387241283161","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-5317-7.00004-7"},{"key":"bibr3-10406387241283161","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.355744"},{"key":"bibr4-10406387241283161","first-page":"16","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","volume":"1","author":"Craig LE","edition":"6"},{"key":"bibr5-10406387241283161","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31732"},{"key":"bibr6-10406387241283161","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy336"},{"key":"bibr7-10406387241283161","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09215.2000"},{"key":"bibr8-10406387241283161","volume":"10","author":"Kuberappa 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