{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:33:37Z","timestamp":1788622417633,"version":"build-2803163510"},"reference-count":57,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>A 2-y-old, intact female, mixed-breed dog was presented to the veterinary hospital with abdominal distension, anemia, and lethargy following a chronic history of nonspecific gastrointestinal signs. CBC and serum biochemistry revealed moderate nonregenerative anemia with neutrophilia, hypoalbuminemia, hyperglobulinemia, hypoglycemia, decreased urea and creatinine, and hypercholesterolemia. Abdominal radiographs and ultrasound revealed a large heterogeneous mesenteric mass and ascites. Abdominocentesis confirmed septic peritonitis with filamentous bacteria. Fine-needle aspiration of the mass yielded pyogranulomatous inflammation and hyphae. An exploratory laparotomy revealed a large cranial abdominal mass with granulomas present throughout the abdominal cavity. Due to the poor prognosis and disseminated disease, the owner elected euthanasia. Postmortem and histologic examinations detected intralesional mycetomas and bacterial colonies within the mesenteric masses. 16S ribosomal RNA gene PCR and sequencing using formalin-fixed, paraffin-embedded sections identified Nocardia yamanashiensis, Nocardioides cavernae, and Nocardioides zeicaulis. Fungal culture, PCR, and sequencing confirmed Scedosporium apiospermum. Our report highlights the importance of molecular methods in conjunction with culture and histologic findings for diagnosing coinfections caused by infrequent etiologic agents. Additionally, we provide a comprehensive literature review of Scedosporium apiospermum infections in dogs.<\/jats:p>","DOI":"10.1177\/10406387241287799","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:53:22Z","timestamp":1728881602000},"page":"189-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Intra-abdominal nocardiosis and scedosporiosis in a dog: case report and literature review"],"prefix":"10.1177","volume":"37","author":[{"given":"Jessica Rose","family":"Lambert","sequence":"first","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Colombari","family":"Cheng","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6105-0317","authenticated-orcid":false,"given":"Laura M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Raiford","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Zuber","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Kilbane","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Fish","sequence":"additional","affiliation":[{"name":"EJF Veterinary Consulting, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kr\u00f3lak","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn C.","family":"Hlusko","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"McMichael","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-0439","authenticated-orcid":false,"given":"Rebecca P.","family":"Wilkes","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Animal Disease Diagnostic Laboratory (ADDL), College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie F.","family":"Ca\u00f1ete-Gibas","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-3774","authenticated-orcid":false,"given":"Daniel Felipe","family":"Barrantes Murillo","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"},{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"bibr1-10406387241287799","first-page":"797","volume":"194","author":"Allison N","year":"1989","journal-title":"J Am Vet Med Assoc"},{"key":"bibr2-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1177\/030089161309900424"},{"key":"bibr3-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500117"},{"key":"bibr4-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.259-282.2006"},{"key":"bibr5-10406387241287799","first-page":"50","volume":"39","author":"Brown JS","year":"2009","journal-title":"Aust Vet Pract"},{"key":"bibr6-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.9.2755-2758.1998"},{"key":"bibr7-10406387241287799","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12040579"},{"key":"bibr8-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.6.175"},{"key":"bibr9-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2005.36473"},{"key":"bibr10-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00039-07"},{"key":"bibr11-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-020-02597-9"},{"key":"bibr12-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.05.028"},{"key":"bibr13-10406387241287799","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903380548"},{"key":"bibr14-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12678"},{"key":"bibr15-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.11.012"},{"key":"bibr16-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01122-07"},{"key":"bibr17-10406387241287799","first-page":"3","volume":"1","author":"Gu\u00e9ho E","year":"1991","journal-title":"J Mycol Med"},{"key":"bibr18-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001676"},{"key":"bibr19-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2011.00870.x"},{"key":"bibr20-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1177\/104063870902100119"},{"key":"bibr21-10406387241287799","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/jama.1970.03170190085028","volume":"157","author":"Jang SS","year":"1970","journal-title":"J Am Vet Med Assoc"},{"key":"bibr22-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.02794-0"},{"key":"bibr23-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.000959"},{"key":"bibr24-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks808"},{"key":"bibr25-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12518"},{"key":"bibr26-10406387241287799","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071317"},{"key":"bibr27-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1007\/s13225-014-0295-4"},{"key":"bibr28-10406387241287799","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S249761"},{"key":"bibr29-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02852-12"},{"key":"bibr30-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.10.2413-2416.1994"},{"key":"bibr31-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1080\/00275514.1970.12019019"},{"key":"bibr32-10406387241287799","first-page":"331","volume":"30","author":"Marlar AB","year":"1994","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr33-10406387241287799","first-page":"333","volume":"31","author":"Matteucci G.","year":"2017","journal-title":"Veterinaria (Cremona)"},{"key":"bibr34-10406387241287799","first-page":"637","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","volume":"1","author":"Mauldin EA","edition":"6"},{"key":"bibr35-10406387241287799","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0670"},{"key":"bibr36-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.438"},{"key":"bibr37-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12313"},{"key":"bibr38-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01012.x"},{"key":"bibr39-10406387241287799","first-page":"59","volume":"39","author":"Paul AEH","year":"2009","journal-title":"Aust Vet Pract"},{"key":"bibr40-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx113"},{"key":"bibr41-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myaa016"},{"key":"bibr42-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.11.2797-2800.1992"},{"key":"bibr43-10406387241287799","first-page":"268","volume":"91","author":"Singh AD","year":"2022","journal-title":"Vlaams Diergeneeskd Tijdschr"},{"key":"bibr44-10406387241287799","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.200.02.199"},{"key":"bibr45-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2018.08.004"},{"key":"bibr46-10406387241287799","first-page":"714","volume-title":"Greene\u2019s Infectious Diseases of the Dog and Cat","volume":"2023","author":"Sykes JE","edition":"5"},{"key":"bibr47-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2014.10.001"},{"key":"bibr48-10406387241287799","first-page":"13","volume":"105","author":"Thiel C","year":"2018","journal-title":"Wien Tierarztl Monatsschr"},{"key":"bibr49-10406387241287799","first-page":"651","volume-title":"The Prokaryotes: Actinobacteria","volume":"2014","author":"T\u00f3th EM","edition":"4"},{"key":"bibr50-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00027-21"},{"key":"bibr51-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2021.05.003"},{"key":"bibr52-10406387241287799","first-page":"269","volume":"16","author":"Tuntivanich P.","year":"1980","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr53-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01234-10"},{"key":"bibr54-10406387241287799","first-page":"67","volume":"192","author":"Walker RL","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"bibr55-10406387241287799","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1995.207.01.67"},{"key":"bibr56-10406387241287799","first-page":"977","volume-title":"Clinical Small Animal Internal Medicine","volume":"2","author":"Whitney J","edition":"1"},{"key":"bibr57-10406387241287799","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2023.100611"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387241287799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387241287799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387241287799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:27:53Z","timestamp":1777681673000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387241287799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/10406387241287799"],"URL":"https:\/\/doi.org\/10.1177\/10406387241287799","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]}}}