{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:23:18Z","timestamp":1792473798275,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Neoplasia is a common disease in guinea pigs ( Cavia porcellus); however, few studies have evaluated the prevalence of neoplasia in all organ systems. We retrospectively analyzed the tumor prevalence in pet guinea pigs and the frequency of metastasis in a multi-institutional study population of 2,474 autopsy cases. Tumors were found in 508 guinea pigs (prevalence: 20.5%), of which 95 cases had &gt;1 tumor, resulting in a total of 627 tumors. The tumor prevalence increased from 1.4% in animals &lt;0.5-y-old to 53.6% for guinea pigs &gt;5-y-old. The most common tumor type was lymphoma or leukemia, affecting 174 guinea pigs (tumor prevalence: 7.0%). Lymphomas or leukemias were disseminated to various organs and\/or lymph nodes in 146 (83.9%) cases and localized to 1 organ or 1 lymph node in 28 (16.1%) cases. Primary non-lymphoid tumors were most frequent in the female genital tract (62 of 1,235 cases, mostly uterus), respiratory system (116 of 2,474), skin including mammary gland (81 of 2,474), endocrine system (66 of 2,474, mostly thyroid gland), and alimentary tract (35 of 2,474). Tumors of the alimentary tract were dominated by gastrointestinal stromal tumors. Metastasis was detected in 42 of 453 non-lymphoid tumors (9.3%), with a surprisingly low frequency for pulmonary carcinoma and splenic hemangiosarcoma compared to other species. Our postmortem study demonstrates a high prevalence of disseminated lymphoma or leukemia in pet guinea pigs at the time of death or euthanasia. Additional studies are needed to further characterize these tumors.<\/jats:p>","DOI":"10.1177\/10406387241288642","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:55:13Z","timestamp":1728881713000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Neoplasia in pet guinea pigs: a retrospective analysis of 2,474 autopsy examinations"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2402-9997","authenticated-orcid":false,"given":"Christof A.","family":"Bertram","sequence":"first","affiliation":[{"name":"Institute of Pathology, University of Veterinary Medicine Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn A.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Schwarzman Animal Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Bertram","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"Das Tierarztpraxis Team Dr. Michael M\u00fcller, Z\u00fclpich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sabara","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klopfleisch","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"bibr1-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2020.02.014"},{"key":"bibr2-10406387241288642","unstructured":"Bertram B. Retrospektive Untersuchungen von Tumorerkrankungen des Meerschweinchens (\n                      Cavia porcellus\n                      ) [Retrospective investigation of neoplastic disorders in guinea pigs (\n                      Cavia porcellus\n                      )]. Dissertation. Freie Universit\u00e4t Berlin, 2023. German. https:\/\/dx.doi.org\/10.17169\/refubium-40716"},{"key":"bibr3-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820973460"},{"key":"bibr4-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13142"},{"key":"bibr5-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2018.09.001"},{"key":"bibr6-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1177\/1040638715578878"},{"key":"bibr7-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2023.04.001"},{"key":"bibr8-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12668"},{"key":"bibr9-10406387241288642","doi-asserted-by":"publisher","DOI":"10.2460\/javma.249.12.1415"},{"key":"bibr10-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812447828"},{"key":"bibr11-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810380397"},{"key":"bibr12-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2018.02.044"},{"key":"bibr13-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2004.04.009"},{"key":"bibr14-10406387241288642","doi-asserted-by":"publisher","DOI":"10.15654\/TPK-161148"},{"key":"bibr15-10406387241288642","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.4.522"},{"key":"bibr16-10406387241288642","doi-asserted-by":"publisher","DOI":"10.2754\/avb200372020221"},{"key":"bibr17-10406387241288642","doi-asserted-by":"publisher","DOI":"10.2754\/avb200978020287"},{"key":"bibr18-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2013.05.006"},{"key":"bibr19-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2016.10.012"},{"key":"bibr20-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00920.x"},{"key":"bibr21-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.08.016"},{"key":"bibr22-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2017.03.002"},{"key":"bibr23-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1622807"},{"key":"bibr24-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2011.07.007"},{"key":"bibr25-10406387241288642","doi-asserted-by":"publisher","DOI":"10.2460\/javma.20.12.0698"},{"key":"bibr26-10406387241288642","first-page":"640","volume":"57","author":"Meurer J","year":"2012","journal-title":"Kleintierpraxis"},{"key":"bibr27-10406387241288642","doi-asserted-by":"publisher","DOI":"10.2754\/avb202392040375"},{"key":"bibr28-10406387241288642","doi-asserted-by":"publisher","DOI":"10.3390\/ani12080965"},{"key":"bibr29-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2022.12.004"},{"key":"bibr30-10406387241288642","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2020.06.002"},{"key":"bibr31-10406387241288642","volume":"11","author":"Rozolen JM","year":"2021","journal-title":"Animals (Basel)"},{"key":"bibr32-10406387241288642","unstructured":"Sabara J. Retrospektive Auswertung der H\u00e4ufigkeit von Neoplasien bei Meerschweinchen [Retrospective evaluation of the prevalence of neoplasia in guinea pigs]. University of Veterinary Medicine Vienna, 2023. 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