{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:48:35Z","timestamp":1791863315033,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"California Animal Health and Food Safety Laboratory, UCDavis"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    Spontaneous intoxication by\n                    <jats:italic>Astragalus arequipensis<\/jats:italic>\n                    was diagnosed in a flock of 300 sheep in Jujuy province, northwestern Argentina, that grazed an area heavily invaded by this plant. The main clinical signs were intention tremors, ataxia, and progressive loss of condition. Autopsy of 2 affected animals revealed loss of body condition. The main microscopic changes were fine cytoplasmic vacuolation of cells in the cerebrum, cerebellum, thyroid and adrenal glands, kidney, liver, pancreas, urinary bladder, and lymph nodes, and swollen axons in the cerebellum. Ultrastructurally, the cytoplasmic vacuoles consisted of dilated secondary lysosomes. Composite leaf and stem samples of\n                    <jats:italic>A. arequipensis<\/jats:italic>\n                    analyzed by high-performance liquid chromatography contained 0.05% swainsonine. The diagnosis of intoxication by\n                    <jats:italic>A. arequipensis<\/jats:italic>\n                    was made based on the clinical history and signs; gross, microscopic, and ultrastructural changes; and detection of swainsonine in the plant.\n                  <\/jats:p>","DOI":"10.1177\/10406387241311815","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:57:31Z","timestamp":1738101451000},"page":"375-379","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Intoxication of sheep by\n                    <i>Astragalus arequipensis<\/i>\n                    in northwestern Argentina"],"prefix":"10.1177","volume":"37","author":[{"given":"Raul E.","family":"Marin","sequence":"first","affiliation":[{"name":"Faculty of Agricultural Sciences, National University of Jujuy, Jujuy, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Gardner","sequence":"additional","affiliation":[{"name":"Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cook","sequence":"additional","affiliation":[{"name":"Poisonous Plant Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Logan, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-9945","authenticated-orcid":false,"given":"Anibal G.","family":"Armien","sequence":"additional","affiliation":[{"name":"Davis branches, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e H.","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Institute of Botany Darwinian (CONICET\/ANCEFYN), National Scientific and Technical Research Council, San Isidro, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-7785","authenticated-orcid":false,"given":"Franklin","family":"Riet-Correa","sequence":"additional","affiliation":[{"name":"Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-1878","authenticated-orcid":false,"given":"Francisco A.","family":"Uzal","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino branches, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-2-170"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231180488"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.11.013"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1071\/CH9792257"},{"key":"e_1_3_2_6_2","first-page":"177","article-title":"Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning","volume":"44","author":"Colodel EM","year":"2002","unstructured":"Colodel EM, et al Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning. 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