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During a routine medical examination, an ovarian mass was found in a 5-y-old female mixed-breed dog. Histologically, the ovarian mass was well-defined, expansile, and composed of large polygonal cells resembling well-differentiated neurons and scattered smaller cells resembling glial cells. Immunohistochemically, the neuron-like cells were positive for neuronal nuclei; the smaller cells were positive for glial fibrillar acidic protein, oligodendrocyte transcription factor 2, and ionized calcium\u2013binding adaptor protein-1. 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