{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:41:58Z","timestamp":1777930918039,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Hypertrophic osteopathy (HO) is a condition in which periosteal bone forms along long bone diaphyses and metaphyses. Lesions generally affect all 4 limbs, and often involve the distal portions. The pathogenesis is incompletely understood, and many, but not all, cases are associated with concurrent neoplasia or space-occupying masses. Among veterinary species, most cases are reported in dogs, cats, and horses, with sporadic cases in other domestic and non-domestic species. In cervids, this condition is often associated with fungal granulomas, typically in the lung. We report HO, with findings consistent to other veterinary species, in a farmed white-tailed deer (WTD) with bacterial pneumonia and in 3 free-ranging WTD, one of which had fungal pneumonia. Recognition of HO in WTD and potentially associated conditions can lead to improved sample collection in the field. Such information can improve characterization of the disease, complement our understanding of comparative pathology of this condition, and raise awareness among individuals or institutions working with cervids.<\/jats:p>","DOI":"10.1177\/10406387251318413","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:23:26Z","timestamp":1738801406000},"page":"340-344","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertrophic osteopathy in 4 white-tailed deer, with a literature review"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5961-8732","authenticated-orcid":false,"given":"Alisia A. W.","family":"Weyna","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison, WI, USA"},{"name":"Southeastern Cooperative Wildlife Disease Study, Departments of Population Health, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Luley","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA, USA"},{"name":"Bureau of Animal Health and Diagnostic Services, Pennsylvania Department of Agriculture, Harrisburg, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-5621","authenticated-orcid":false,"given":"Kevin D.","family":"Niedringhaus","sequence":"additional","affiliation":[{"name":"Southeastern Cooperative Wildlife Disease Study, Departments of Population Health, University of Georgia, Athens, GA, USA"},{"name":"Wildlife Futures Program, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha E. J.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Southeastern Cooperative Wildlife Disease Study, Departments of Population Health, University of Georgia, Athens, GA, USA"},{"name":"National Wildlife Refuge System, United States Fish and Wildlife Service, Chiefland, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-175X","authenticated-orcid":false,"given":"Nicole M.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Southeastern Cooperative Wildlife Disease Study, Departments of Population Health, University of Georgia, Athens, GA, USA"},{"name":"Pathology, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-6-499"},{"key":"e_1_3_3_3_2","first-page":"1242","article-title":"Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases","volume":"159","author":"Brodey RS.","year":"1971","unstructured":"Brodey RS. Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases. J Am Vet Med Assoc 1971;159:1242\u20131256.","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_3_3_4_2","article-title":"Hypertrophic osteoarthropathy in a sheep","volume":"50","author":"Chaves Bom HA","year":"2020","unstructured":"Chaves Bom HA, et al. Hypertrophic osteoarthropathy in a sheep. Cienc Rural 2020;50:e20191038.","journal-title":"Cienc Rural"},{"key":"e_1_3_3_5_2","first-page":"16","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","author":"Craig LE","unstructured":"Craig LE, et al. Bones and joints. In: Maxie MG, ed. Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals. 6th ed. Vol. 1. Elsevier, 2016:16\u2013163.","edition":"6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2006.03.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2019.20.e52"},{"key":"e_1_3_3_8_2","article-title":"Renal adenocarcinoma associated with hypertrophic osteopathy in a cat","volume":"6","author":"Elhamiani Khatat S","year":"2020","unstructured":"Elhamiani Khatat S, et al. Renal adenocarcinoma associated with hypertrophic osteopathy in a cat. JFMS Open Rep 2020;6:2055116920962433.","journal-title":"JFMS Open Rep"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063870802000628"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/avj.13052"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.201.12.1900"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063870902100131"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1996.tb03088.x"},{"key":"e_1_3_3_14_2","first-page":"741","article-title":"Hypertrophic osteopathy associated with hepatocellular carcinoma in a dog","volume":"56","author":"Randall VD","year":"2015","unstructured":"Randall VD, et al. Hypertrophic osteopathy associated with hepatocellular carcinoma in a dog. Can Vet J 2015;56:741\u2013744.","journal-title":"Can Vet J"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9090466"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2004.tb00316.x"},{"key":"e_1_3_3_17_2","first-page":"393","volume-title":"Dtsch Tierarztl Wochenschr","author":"Schulze C","year":"2005","unstructured":"Schulze C, et al. Hypertrophe Osteopathie beim Reh (Capreolus capreolus) [Case report: Hypertrophic osteopathy in roe deer (Capreolus capreolus)]. Dtsch Tierarztl Wochenschr 2005;112:393\u2013394. German."},{"key":"e_1_3_3_18_2","unstructured":"Thorsson E. Hypertrophic osteoarthropathy in wildlife: and a review of suggested pathogeneses. Essay. Department of Biomedical Sciences and Veterinary Public Health Swedish University of Agricultural Sciences 2015. https:\/\/stud.epsilon.slu.se\/7926\/"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0652.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.7589\/2017-07-171"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12026"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160052"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387251318413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387251318413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387251318413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:28:17Z","timestamp":1777681697000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387251318413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/10406387251318413"],"URL":"https:\/\/doi.org\/10.1177\/10406387251318413","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]}}}