{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:42:13Z","timestamp":1777930933447,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sagepub.com\/licence-information-for-chorus"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009035","name":"Program on Open Innovation Platform with Enterprises, Research Institute and Academia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19242"],"award-info":[{"award-number":["22K19242"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02380"],"award-info":[{"award-number":["23H02380"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Mammary tumor\u2013associated amyloidosis in dogs has been reported in several studies, but its incidence and predisposing conditions have not been investigated. We examined 252 mammary masses from 183 dogs to determine the prevalence of amyloid deposition and elucidate etiologic factors. Histologically, amyloid deposition was observed in 88 of 252 (35%) mammary masses. Amyloid deposition patterns were categorized into 3 types: stromal deposition (ST), deposition in corpora amylacea (CA), and precipitation within luminal secretions (PR). Of the 88 amyloid deposition cases, 49 were intra-tumoral, especially for ST-type amyloid deposits, which were all intra-tumoral. Immunohistochemistry and mass spectrometry revealed that ST-type amyloid deposits were positive for either serum amyloid A or \u03b1-S1-casein, depending on the sample; all CA- and PR-type amyloid deposits were positive for \u03b1-S1-casein. Statistically, intra-tumoral ST-type amyloid deposition was significantly more frequent in histologic grade II (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009) or III (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) mammary tumors. In contrast, amyloid deposition in extra-tumoral tissues is significantly associated with aging (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Our findings suggest that the disruption of proteostasis in the canine mammary gland associated with tumorigenesis and aging can readily induce amyloid formation.\n                  <\/jats:p>","DOI":"10.1177\/10406387251328323","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T02:15:37Z","timestamp":1743560137000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of amyloid deposits in canine mammary neoplasms"],"prefix":"10.1177","volume":"37","author":[{"given":"Yuka","family":"Kato","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0601-9137","authenticated-orcid":false,"given":"Susumu","family":"Iwaide","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumpei","family":"Hisamoto","sequence":"additional","affiliation":[{"name":"Meiji Institute for Advanced Study of Mathematical Sciences, Nakano-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Laboratory of Ethology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Smart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Hisada","sequence":"additional","affiliation":[{"name":"Smart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Machida","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Nomura","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, MLT, Ikeda, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-7842","authenticated-orcid":false,"given":"Tomoaki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2022.140854"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0302231"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-6-718"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/80.1.27"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-6831"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858241283750"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820934113"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858221128924"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858241230100"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10020166"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813511128"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858221148511"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(72)90040-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0464-5"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-1-104"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0482"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200409"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8561"},{"key":"e_1_3_2_20_2","volume-title":"Surgical Pathology of Tumors of Domestic Animals","author":"Zappulli V","year":"2019","unstructured":"Zappulli V, et al. 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Davis-Thompson Foun-dation, 2019."}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387251328323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387251328323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387251328323","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387251328323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:28:53Z","timestamp":1777681733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387251328323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/10406387251328323"],"URL":"https:\/\/doi.org\/10.1177\/10406387251328323","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}