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We conducted proteome analysis using liquid chromatography\u2013tandem mass spectrometry to identify the amyloid precursor protein in a 13-y-old male mixed-breed dog with amyloid deposition in intramural coronary arteries, and identified fibrinogen A\u03b1-chain. This form of amyloidosis is characterized by the deposition of amyloid derived from fibrinogen A\u03b1-chains, which has been reported previously only in humans and Japanese squirrels. Within amyloid deposits in the intramural coronary arteries of our canine case, the \u03b1C connector region was identified in abundance, whereas in humans and Japanese squirrels, the amyloid arises from the \u03b1C domain. 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