{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:42:18Z","timestamp":1777930938000,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Spurious platelet counts (PLTCs) associated with lipemia are documented in humans and rarely in dogs. We retrospectively evaluated CBCs of dogs admitted to a veterinary hospital to assess the interference of lipemia with the automated PLTC (A-PLTC) measured by an optical method (Advia 2120i; Siemens). The severity of lipemia was used to group CBC results into 2 groups: severe lipemia (SL) and non-severe lipemia (NSL). Samples with abnormalities other than lipemia, potentially associated with a spurious increase in PLTC, were excluded. In the SL group, a manual PLTC (M-PLTC) was performed, and its difference with A-PLTC (\u0394APLT-MPLT) was calculated. Platelet scatter plots, concentration of triglycerides and cholesterol, diseases, and therapies were evaluated. We selected 9,535 samples, 173 (1.9%) in the SL group and 9,362 in the NSL group. The A-PLTC was significantly increased in the SL group (median: 399\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L; range: 11\u20131,900\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) compared to the NSL group (median: 300\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, range: 1\u20132,250\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). In the SL group, A-PLTC was significantly increased compared to M-PLTC (median: 356\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, range: 24\u20131,170\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01; median: \u0394APLT-MPLT +25\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, range: \u2013190 to 1,700\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L), and the triglyceride concentration (median: 8.71\u2009mmol\/L; range: 0.55\u2013152\u2009mmol\/L) was significantly associated with \u0394APLT-MPLT (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.05;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004). Dogs with pancreatitis had significantly increased \u0394APLT-MPLT (median: +624\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L; range: 62\u20131,700\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) compared to other disease categories (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01). Severe lipemia may be associated with a spurious A-PLTC increase in dogs; careful evaluation of platelet scatter plots and visual inspection of serum are recommended. Manual estimation is required to correct the A-PLTC when this artifact is detected.\n                  <\/jats:p>","DOI":"10.1177\/10406387251355250","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:56:37Z","timestamp":1754906197000},"page":"862-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spurious increase in automated optical platelet counts associated with lipemia in dogs"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-1080","authenticated-orcid":false,"given":"Sabrina","family":"Fasoli","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1834-0771","authenticated-orcid":false,"given":"Kateryna","family":"Vasylyeva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-573X","authenticated-orcid":false,"given":"Maria Giulia","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-8257","authenticated-orcid":false,"given":"Francesco","family":"Lunetta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Brini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-3653","authenticated-orcid":false,"given":"Marta","family":"Gruarin","sequence":"additional","affiliation":[{"name":"University of Nottingham, School of Veterinary Sciences, Sutton Bonington, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-3834","authenticated-orcid":false,"given":"Chiara","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-6458","authenticated-orcid":false,"given":"Francesco","family":"Dondi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030808"},{"key":"e_1_3_3_3_2","first-page":"511","volume-title":"Schalm\u2019s Veterinary Hematology","author":"Borgatti A.","year":"2011","unstructured":"Borgatti A. 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