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Elevated liver enzyme activities and mild anemia were present antemortem. Generalized jaundice and a diffusely yellow liver with dark-red foci were noted at postmortem examination. Cytologically, hepatocytes contained abundant fine-to-large vacuoles, and multinucleate giant hepatocytes were present. Histologically, the liver had severe centrilobular necrosis, severe biliary congestion, and multinucleation of hepatocytes, leading to the diagnosis of giant cell hepatitis. In addition, flukes present in bile ducts were identified as\n                    <jats:italic toggle=\"yes\">Platynosomum illiciens<\/jats:italic>\n                    by morphologic and molecular analyses. These flukes were genetically similar to\n                    <jats:italic toggle=\"yes\">P. illiciens<\/jats:italic>\n                    in Southeast Asia and South America.\n                  <\/jats:p>","DOI":"10.1177\/10406387251365607","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:26:39Z","timestamp":1756455999000},"page":"942-947","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant cell hepatitis with\n                    <i>Platynosomum illiciens<\/i>\n                    infection in a Japanese domestic cat"],"prefix":"10.1177","volume":"37","author":[{"given":"Natsumi","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-9068","authenticated-orcid":false,"given":"Aya","family":"Masuda","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Zoology, Nihon University, Fujisawa, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Zoology, Nihon University, Fujisawa, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Asai","sequence":"additional","affiliation":[{"name":"Shinnarashino Animal Hospital, Narashino, Chiba, Japan"},{"name":"Kanadenomori Animal Hospital, Narashino, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Hida","sequence":"additional","affiliation":[{"name":"Kanadenomori Animal Hospital, Narashino, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-7842","authenticated-orcid":false,"given":"Tomoaki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.04.015"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90079-Q"},{"key":"e_1_3_3_4_2","first-page":"306","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","author":"Cullen JM","unstructured":"Cullen JM, et al. 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J Clin Transl Pathol 2022;2:100\u2013107.","journal-title":"J Clin Transl Pathol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2010.26.3.307"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.03.030"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2017.55.1.39"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102143240705"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X15000152"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3926-5"},{"key":"e_1_3_3_17_2","first-page":"188","volume":"38","author":"Pinto HA","year":"2022","unstructured":"Pinto HA, et al. Platynosomum illiciens. 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