{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:42:19Z","timestamp":1777930939573,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Spontaneous ejection of tissues from body orifices is rare in veterinary medicine. Here we underscore the diagnostic value of tissues spontaneously ejected from the nose or mouth of 21 dogs and submitted for histologic evaluation at 3 veterinary diagnostic institutions. Cases were retrospectively searched (2000\u20132024) from the Athens Veterinary Diagnostic Laboratory, Tifton Veterinary Diagnostic and Investigational Laboratory, and Antech Diagnostics web-based archive systems. Affected dogs were adults (x\u0304 age\u2009=\u20099.5\u2009y) of several breeds. There were 13 male (8 castrated, 5 intact) and 8 spayed female dogs. Clinical signs consisted mainly of sneezing (19 of 21 cases) and epistaxis (11 cases), with spontaneous ejection of red-to-brown and fleshy-or-spongy nodules from the nose (19 cases) or mouth (2). Histologically, lesions consisted of neoplasms (19 cases) or clusters of fibrinous or suppurative exudate with hemorrhage (2). Epithelial neoplasms consisted of carcinomas and adenocarcinomas (3 cases each), and squamous cell carcinoma and a presumed adenoma (1 case each). Mesenchymal neoplasms consisted of spindle-cell sarcomas (4 cases), presumed osteosarcomas (2), and a chondrosarcoma and a chondrosarcoma\/chondroblastic osteosarcoma (1 case each). Round-cell neoplasms included a B-cell lymphoma, a presumed lymphoma, and a plasmacytoma (1 case each). The presence of nasal mucosa and turbinates was supportive of nasal tumor in 4 cases. Although the anatomic origin of neoplasms cannot be determined in all cases, tissues ejected from the nose or mouth can be suitable for a histologic diagnosis.<\/jats:p>","DOI":"10.1177\/10406387251368304","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:03:21Z","timestamp":1756976601000},"page":"956-961","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous oronasal ejection of neoplastic and non-neoplastic nodules by 21 dogs, 2000\u20132024"],"prefix":"10.1177","volume":"37","author":[{"given":"Daniel A. Sebastian","family":"Pineda","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano N.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Antech Diagnostics, College Station, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1705-2865","authenticated-orcid":false,"given":"Erin A.","family":"Graham","sequence":"additional","affiliation":[{"name":"Tifton Veterinary Diagnostic and Investigational Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3479","authenticated-orcid":false,"given":"Ricardo E.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2836","authenticated-orcid":false,"given":"Daniel R.","family":"Rissi","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Huge antrochoanal polyp: a case report","volume":"15","author":"Alharbi SM","year":"2023","unstructured":"Alharbi SM, et al. Huge antrochoanal polyp: a case report. Cureus 2023;15:e45592.","journal-title":"Cureus"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-143"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100504"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.1994.tb09773.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-6638"},{"key":"e_1_3_3_7_2","article-title":"Spontaneous expulsion of a submucosal uterine fibroid without embolization in a pre-menopausal woman","volume":"8","author":"Rios SDS","year":"2020","unstructured":"Rios SDS, et al. Spontaneous expulsion of a submucosal uterine fibroid without embolization in a pre-menopausal woman. SAGE Open Med Case Rep 2020;8:2050313X20922743.","journal-title":"SAGE Open Med Case Rep"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.24070\/bjvp.1983-0246.v17i1p58-59"},{"key":"e_1_3_3_9_2","first-page":"551","volume-title":"Internist (Berl)","author":"Scheppach W","year":"2022","unstructured":"Scheppach W, et al. Spontanabgang eines mesenchymalen Kolontumors per vias naturales [Spontaneous expulsion of a mesenchymal colonic tumor via the rectum]. Internist (Berl) 2022;63:551\u2013555. German."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.14740\/gr1054w"},{"key":"e_1_3_3_11_2","first-page":"467","volume-title":"Tumors in Domestic Animals","author":"Wilson DW","unstructured":"Wilson DW. Tumors of the respiratory tract. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. 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